Phenotypes associated with this allele

• Allele Symbol: Dna2^tm1.1Lzhg
• Allele Name: targeted mutation 1.1, Li Zheng
• Allele ID: MGI:5515895
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dna2^tm1.1Lzhg/Dna2^tm1.1Lzhg	involves: 129S1/Sv	MGI:5515899
ht2	Dna2^tm1.1Lzhg/Dna2^+	involves: 129S1/Sv	MGI:5515898

Genotype
MGI:5515899

hm1

• Allelic Composition: Dna2^tm1.1Lzhg/Dna2^tm1.1Lzhg
• Genetic Background: involves: 129S1/Sv

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:198831 )

• no mice are recovered at E7.5

Genotype
MGI:5515898

ht2

• Allelic Composition: Dna2^tm1.1Lzhg/Dna2⁺
• Genetic Background: involves: 129S1/Sv

cellular

abnormal chromosome morphology ( J:198831 )

• increased number of anaphase chromosome bridges in mouse embryonic fibroblasts

aneuploidy ( J:198831 )

• in adenocarcinoma cells

abnormal telomere morphology ( J:198831 )

• mouse embryonic fibroblasts exhibit fragile telomeres and sister telomere associations and other telomeric abnormalities

• G4 stabilizing molecules increase fragile telomeres in mouse embryonic fibroblasts

• increased telomere DNA damage

decreased telomere length ( J:198831 )

• short telomere length in lung cells and more so in lung cancer cells

abnormal mitosis ( J:198831 )

• increased chromosome segregation errors

chromosomal instability ( J:198831 )

• increased chromosome breaks in mouse embryonic cells treated with aphidicodin

• in adenocarcinoma cells

liver/biliary system

increased hepatoma incidence ( J:198831 )

• in some mice

neoplasm

increased hepatoma incidence ( J:198831 )

• in some mice

increased lymphoma incidence ( J:198831 )

• in some mice

increased lung adenocarcinoma incidence ( J:198831 )

• in some mice

respiratory system

increased lung adenocarcinoma incidence ( J:198831 )

• in some mice