About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Braptm1.1Yfng
targeted mutation 1.1, Yuanyi Feng
MGI:5515812
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Braptm1.1Yfng/Braptm1.1Yfng involves: C57BL/6 * FVB/N MGI:5515912
cx2
 		Braptm1.1Yfng/Braptm1.1Yfng
Pafah1b1tm1Awb/Pafah1b1+ 		involves: 129S6/SvEvTac * C57BL/6 * FVB/N MGI:5515911


Genotype
MGI:5515912
hm1
Allelic
Composition		 Braptm1.1Yfng/Braptm1.1Yfng
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braptm1.1Yfng mutation (0 available); any Brap mutation (30 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis ( J:197131 )
• survive to E12 but die before E13

growth/size/body
growth/size/body region phenotype ( J:197131 )
N
• little difference in size and morphology from controls

cellular
abnormal mitosis ( J:197131 )
• subtle differences in interkinetic nuclear migration
• about 85% of neuron progenitors with metaphase chromosomes properly positioned




Genotype
MGI:5515911
cx2
Allelic
Composition		 Braptm1.1Yfng/Braptm1.1Yfng
Pafah1b1tm1Awb/Pafah1b1+
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Braptm1.1Yfng mutation (0 available); any Brap mutation (30 available)
Pafah1b1tm1Awb mutation (0 available); any Pafah1b1 mutation (158 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis ( J:197131 )
• lethality around E11.5

growth/size/body
decreased embryo size ( J:197131 )

nervous system
abnormal roof plate morphology ( J:197131 )
• roof plate widening

cellular
abnormal mitosis ( J:197131 )
• less than 60% of neuron progenitors with properly positioned metaphase chromosomes

embryo
abnormal roof plate morphology ( J:197131 )
• roof plate widening




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory