Phenotypes associated with this allele

• Allele Symbol: Tg(Lor-CHUK)8Yhu
• Allele Name: transgene insertion 8, Yinling Hu
• Allele ID: MGI:5515803
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cx1	Chuk^tm2Yhu/Chuk^tm2Yhu Tg(Lor-CHUK)8Yhu/0	involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N	MGI:5515883
cx2	Chuk^tm2Yhu/Chuk^tm2Yhu Tg(Lor-CHUK)8Yhu/0	involves: 129S1/Sv * 129X1/SvJ * FVB/N	MGI:5515882

Genotype
MGI:5515883

cx1

• Allelic Composition: Chuk^tm2Yhu/Chuk^tm2Yhu; Tg(Lor-CHUK)8Yhu/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased neutrophil cell number ( J:197037 )

• moderate in the lungs

increased CD4-positive, alpha-beta T cell number ( J:197037 )

• in the lungs

increased CD8-positive, alpha-beta T cell number ( J:197037 )

• moderate in the lungs

increased macrophage cell number ( J:197037 )

• extensive macrophage infiltration into squamous cell carcinoma

lung inflammation ( J:197037 )

• with increased oxidant

• however, macrophage depletions reduces inflammation

respiratory system

lung inflammation ( J:197037 )

• with increased oxidant

• however, macrophage depletions reduces inflammation

neoplasm

increased squamous cell carcinoma incidence ( J:197037 )

• in 2 of 3 mice at 1.2 years of age in the forestomach

• bone marrow reconstitutes lung SCCs in irradiated mice

• however, macrophage depletion prevents SCC development

digestive/alimentary system

stomach mucosa hyperplasia ( J:197037 )

• atypical squamous hyperplasia in the forestomach in all mice at 5 months to 1.2 years

• however, macrophage depletion reduces epithelial proliferation

hematopoietic system

increased neutrophil cell number ( J:197037 )

• moderate in the lungs

increased CD4-positive, alpha-beta T cell number ( J:197037 )

• in the lungs

increased CD8-positive, alpha-beta T cell number ( J:197037 )

• moderate in the lungs

increased macrophage cell number ( J:197037 )

• extensive macrophage infiltration into squamous cell carcinoma

Genotype
MGI:5515882

cx2

• Allelic Composition: Chuk^tm2Yhu/Chuk^tm2Yhu; Tg(Lor-CHUK)8Yhu/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * FVB/N

mortality/aging

premature death ( J:197037 )

• mice do not live longer than 7 or 8 months

neoplasm

increased lung tumor incidence ( J:197037 )

increased lung squamous cell carcinoma incidence ( J:197037 )

• at 4 to 6 months of age without metastases

respiratory system

enlarged lung ( J:197037 )

• associated with tumor development

increased lung tumor incidence ( J:197037 )

increased lung squamous cell carcinoma incidence ( J:197037 )

• at 4 to 6 months of age without metastases

immune system

absent lymph nodes ( J:197037 )

integument

integument phenotype ( J:197037 )

N • mice do not develop skin phenotype observed in Chuk^tm2Yhu homozygotes

growth/size/body

enlarged lung ( J:197037 )

• associated with tumor development