Analysis Tools
mortality/aging
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• homozygous embryos are recovered at expected Mendelian ratios at E7.5 but arrest prior to gastrulation
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• no homozygous embryos are recovered at E9.5
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embryo
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• although a morphological primitive streak has formed, no other hallmarks typical of gastrulating embryos are observed at E7.5
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• embryos arrest prior to gastrulation
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• embryos are smaller than controls at E7.5
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• the epiblast shows very weak Oct4 signal at E7.5
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• no head folds are present at E7.5
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• no embryonic node is present at E7.5
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growth/size/body
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• embryos are smaller than controls at E7.5
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