About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Fetubtm1Wja
targeted mutation 1, Willi Jahnen-Dechent
MGI:5514274
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Fetubtm1Wja/Fetubtm1Wja B6.Cg-Fetubtm1Wja MGI:5514277
hm2
 		Fetubtm1Wja/Fetubtm1Wja D2.Cg-Fetubtm1Wja MGI:5514278


Genotype
MGI:5514277
hm1
Allelic
Composition		 Fetubtm1Wja/Fetubtm1Wja
Genetic
Background		 B6.Cg-Fetubtm1Wja
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fetubtm1Wja mutation (0 available); any Fetub mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:196435 )
N
• male mice are fertile
abnormal zona pellucida morphology ( J:196435 )
• zona pellucida undergoes premature hardening without fertilization
female infertility ( J:196435 )
• however, infertility can be rescued by liver-derived Fetuinb
impaired fertilization ( J:196435 )
• no oocytes show signs of fertilization after natural mating
• however, fertilization is restored by laser perforation of the zona pellucida barrier

cellular
abnormal zona pellucida morphology ( J:196435 )
• zona pellucida undergoes premature hardening without fertilization




Genotype
MGI:5514278
hm2
Allelic
Composition		 Fetubtm1Wja/Fetubtm1Wja
Genetic
Background		 D2.Cg-Fetubtm1Wja
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fetubtm1Wja mutation (0 available); any Fetub mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
reproductive system
reproductive system phenotype ( J:196435 )
N
• male mice are fertile
abnormal zona pellucida morphology ( J:196435 )
• zona pellucida undergoes premature hardening without fertilization
female infertility ( J:196435 )
• however, infertility can be rescued by liver-derived Fetuinb
impaired fertilization ( J:196435 )
• no oocytes show signs of fertilization after natural mating
• however, fertilization is restored by laser perforation of the zona pellucida barrier

cellular
abnormal zona pellucida morphology ( J:196435 )
• zona pellucida undergoes premature hardening without fertilization




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory