Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation
(10 available)
Tgfb1tm3.1Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
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immune system
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• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
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• expansion of thymic and peripheral T reg cells
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hematopoietic system
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• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
|
|
• expansion of thymic and peripheral T reg cells
|
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Cd4-cre)1Cwi mutation
(10 available)
Tgfb1tm3.1Flv mutation
(0 available);
any
Tgfb1 mutation
(34 available)
Tg(TcraBDC2.5,TcrbBDC2.5)1Doi mutation
(3 available)
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immune system
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• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
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• increased frequency of T reg in the thymus and pancreatic lymph nodes
• number of T reg cells in pancreatic lymph nodes is increased as well
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• rapidly develop diabetes but with a low incidence
• slow kinetics of disease progression
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hematopoietic system
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• significantly increased Th1 cell numbers in spleen and pancreatic lymph nodes
|
|
• increased frequency of T reg in the thymus and pancreatic lymph nodes
• number of T reg cells in pancreatic lymph nodes is increased as well
|