Phenotypes associated with this allele

• Allele Symbol: Myo18a^{tm1b(KOMP)Wtsi}
• Allele Name: gtargeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5513803
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo18a^tm1b(KOMP)Wtsi/Myo18a^tm1b(KOMP)Wtsi	C57BL/6N-Myo18a^tm1b(KOMP)Wtsi	MGI:6360585
hm2	Myo18a^tm1b(KOMP)Wtsi/Myo18a^tm1b(KOMP)Wtsi	C57BL/6N-Myo18a^tm1b(KOMP)Wtsi/Tcp	MGI:6262954

Genotype
MGI:6360585

hm1

• Allelic Composition: Myo18a^{tm1b(KOMP)Wtsi}/Myo18a^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Myo18a^{tm1b(KOMP)Wtsi}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:277320 )

• viable embryos are detected at E9.5, E10.5, and E11.5 and only 2 of 12 mutants detected at E12.5 are alive and no mutants are recovered at E13.5

muscle

abnormal muscle fiber morphology ( J:277320 )

• hearts show disorganization of developing myofibrils, sarcomeric disarray, and disruptions of A-bands at E10.5

• embryonic myofibrils are only rarely detected in cardiac myocytes and instead, thick myosin filaments together with I-Z-I brushes are widespread, and a few short sarcomeric formations with loosely packed A-band formations are detected

abnormal sarcomere morphology ( J:277320 )

• hearts show sarcomeric disarray at E10.5

abnormal A band morphology ( J:277320 )

• hearts show disruptions of A-bands at E10.5

Genotype
MGI:6262954

hm2

• Allelic Composition: Myo18a^{tm1b(KOMP)Wtsi}/Myo18a^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Myo18a^{tm1b(KOMP)Wtsi}/Tcp
• Cell Lines: EPD0396_4_E05

Data Sources

IMPC Data for Myo18a

embryo

abnormal embryo size ( J:211773 )

IMPC - TCP

abnormal limb bud morphology ( J:211773 )

IMPC - TCP

abnormal placenta size ( J:211773 )

IMPC - TCP

pale yolk sac ( J:211773 )

IMPC - TCP

growth/size/body

abnormal embryo size ( J:211773 )

IMPC - TCP

integument

pallor ( J:211773 )

IMPC - TCP

limbs/digits/tail

abnormal limb bud morphology ( J:211773 )

IMPC - TCP

liver/biliary system

pale liver ( J:211773 )

IMPC - TCP

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - TCP