All Phenotypes Pax6<Aey80> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pax6^Aey80
abnormality of the eye 80
MGI:5511011

Summary

2 genotypes

Allelic Composition	Pax6^Aey80/Pax6^Aey80
Genetic Background	C3HeB/FeJ-Pax6^Aey80

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Aey80 mutation (0 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

• no homozygotes are identified after birth

vision/eye

anophthalmia ( J:196657 )

• homozygous embryos lack eyes

Allelic Composition	Pax6^Aey80/Pax6⁺
Genetic Background	C3HeB/FeJ-Pax6^Aey80

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pax6^Aey80 mutation (0 available); any Pax6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

vision/eye

vision/eye phenotype ( J:196657 )

N	• the adult lens and cornea are clear • no lens-cornea adhesions as seen in embryos

abnormal eye morphology ( J:196657 )

corneal-lenticular stalk ( J:196657 )

• fusion between the lens and cornea in E15.5 embryos

• synechia between the lens and cornea

small lens ( J:196657 )

• slightly smaller than controls

• significantly reduced lens thickness

abnormal eye size ( J:196657 )

• axial length of the eye is reduced

microphthalmia ( J:196657 )

• small eyes

blindness ( J:196657 )

• as a result of strain background

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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