Phenotypes associated with this allele

• Allele Symbol: Scara5^tm1Ktry
• Allele Name: targeted mutation 1, Karl Tryggvason
• Allele ID: MGI:5510759
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Scara5^tm1Ktry/Scara5^tm1Ktry	B6N.129X1-Scara5^tm1Ktry	MGI:5510773

Genotype
MGI:5510773

hm1

• Allelic Composition: Scara5^tm1Ktry/Scara5^tm1Ktry
• Genetic Background: B6N.129X1-Scara5^tm1Ktry

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal testis morphology ( J:195536 )

♂ • normal phenotype at birth

♂ • pathological changes develop with age in testes

reduced male fertility ( J:195536 )

♂ • decreased fertility due to pathological changes that develop in testes with age

adipose tissue

adipose tissue inflammation ( J:195536 )

• aging mice develop lymphocytic infiltrates in adipose tissue

immune system

adipose tissue inflammation ( J:195536 )

• aging mice develop lymphocytic infiltrates in adipose tissue

increased anti-nuclear antigen antibody level ( J:195536 )

• elevated antinuclear antibodies in 6-8 month old mice relative to age matched controls

liver inflammation ( J:195536 )

• aging mice develop lymphocytic infiltrates in the stroma

urinary bladder inflammation ( J:195536 )

• aging mice develop lymphocytic infiltrates in the stroma

lung inflammation ( J:195536 )

• aging mice develop lymphocytic infiltrates in the stroma

• early stage changes include mild and focal lymphocyte infiltrations with occasional plasma cells, around centrilobular thin walled vessels

• middle phase changes include thick and continuous infiltrates expanding around vessels and bronchioli and expanding into inter-alveolar compartment

• late stage changes include substantial accumulation of immunoglobulin producing plasma cells with Russell bodies, filling of alveoli with macrophage, necrotizing pseudogranulomatous nodules

• advanced lesions in 15% of mice by 6-12 months and in 48% by 12-24 months

interstitial pneumonia ( J:195536 )

• lymphocytic interstitial pneumonia is part of late stage changes

skin inflammation ( J:195536 )

• aging mice develop lymphocytic infiltrates in the stroma

respiratory system

lung inflammation ( J:195536 )

• aging mice develop lymphocytic infiltrates in the stroma

• early stage changes include mild and focal lymphocyte infiltrations with occasional plasma cells, around centrilobular thin walled vessels

• middle phase changes include thick and continuous infiltrates expanding around vessels and bronchioli and expanding into inter-alveolar compartment

• late stage changes include substantial accumulation of immunoglobulin producing plasma cells with Russell bodies, filling of alveoli with macrophage, necrotizing pseudogranulomatous nodules

• advanced lesions in 15% of mice by 6-12 months and in 48% by 12-24 months

interstitial pneumonia ( J:195536 )

• lymphocytic interstitial pneumonia is part of late stage changes

integument

skin inflammation ( J:195536 )

• aging mice develop lymphocytic infiltrates in the stroma

liver/biliary system

liver inflammation ( J:195536 )

• aging mice develop lymphocytic infiltrates in the stroma

renal/urinary system

urinary bladder inflammation ( J:195536 )

• aging mice develop lymphocytic infiltrates in the stroma

endocrine/exocrine glands

abnormal testis morphology ( J:195536 )

♂ • normal phenotype at birth

♂ • pathological changes develop with age in testes