Phenotypes associated with this allele

• Allele Symbol: Crkl^snoopy
• Allele Name: snoopy
• Allele ID: MGI:5510713
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Crkl^snoopy/Crkl^snoopy	involves: C3H/HeH * C57BL/6JAnu	MGI:5510822
hm2	Crkl^snoopy/Crkl^snoopy	involves: C57BL/6JAnu	MGI:7437810

Genotype
MGI:5510822

hm1

• Allelic Composition: Crkl^snoopy/Crkl^snoopy
• Genetic Background: involves: C3H/HeH * C57BL/6JAnu

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Craniofacial and skeletal mutants: (A-D) Fras1^bfb, (E-G) Ift140^cauli, (H-J) knyn, and (K-M) Crkl^snoopy homozygotes

vision/eye

abnormal eye development ( J:199856 )

• poorly developed at E13.5

cyclopia ( J:199856 )

• in some mice

ocular hypotelorism ( J:199856 )

• at E13.5

craniofacial

absent mandible ( J:199856 )

• hypoplasia/aplasia at E13.5

mandible hypoplasia ( J:199856 )

• hypoplasia/aplasia at E13.5

nervous system

holoprosencephaly ( J:199856 )

• some mice exhibit complete failure of forebrain vesicle separation

abnormal forebrain morphology ( J:199856 )

• at E13.5

skeleton

absent mandible ( J:199856 )

• hypoplasia/aplasia at E13.5

mandible hypoplasia ( J:199856 )

• hypoplasia/aplasia at E13.5

growth/size/body

absent mandible ( J:199856 )

• hypoplasia/aplasia at E13.5

mandible hypoplasia ( J:199856 )

• hypoplasia/aplasia at E13.5

Genotype
MGI:7437810

hm2

• Allelic Composition: Crkl^snoopy/Crkl^snoopy
• Genetic Background: involves: C57BL/6JAnu

craniofacial

abnormal craniofacial morphology ( J:251775 )

• at E10.5, embryos exhibit a range of orofacial malformations with variable expressivity

• in severely affected embryos, failure of maxillary and mandibular structures occurs in conjunction with microphthalmia or anophthalmia and holoprosencephaly

• craniofacial defects are frequently bilateral; however, a significant proportion of embryos show asymmetric defects, esp. in the mandible

abnormal basisphenoid bone morphology ( J:251775 )

• at E17.5, the basisphenoid shows long, ectopic lateral processes that pass below, but are not fused to the tympanic bullae

basisphenoid bone hypoplasia ( J:251775 )

• at E17.5, the basisphenoid bone is hypoplastic

abnormal zygomatic arch morphology ( J:251775 )

• at E17.5, the zygomatic arch is reduced in size

abnormal mandible morphology ( J:251775 )

• at E17.5, the mandibular skeleton is severely dysmorphic and the hemimandibles are prematurely fused distally

absent mandible ( J:251775 )

• at E10.5, the mandible is variably affected, ranging from mild mandibular hypoplasia to agnathia

mandible hypoplasia ( J:251775 )

• at E10.5, the mandible is variably affected, ranging from mild mandibular hypoplasia to agnathia

premaxilla hypoplasia ( J:251775 )

• at E17.5, the maxilla/premaxilla are mildly hypoplastic

maxilla hypoplasia ( J:251775 )

• at E13.5, maxillary hypoplasia often accompanies mandibular hypoplasia

• at E17.5, the maxilla/premaxilla are mildly hypoplastic

abnormal palatine bone morphology ( J:251775 )

• at E17.5, the prepalatine bones are absent, and the palatine bones are reduced in length posteriorly

abnormal palatal shelf morphology ( J:251775 )

• at E13.5, embryos with aglossia exhibit expanded and irregular palatal shelves

• however, when the tongue is present, palatal shelves take on a more normal morphology

increased palatal shelf size ( J:251775 )

• at E13.5, embryos with aglossia exhibit dramatically expanded and bulbous palatal shelves that fill most of the oral cavity

decreased mouth size ( J:251775 )

abnormal oral cavity morphology ( J:251775 )

• in severely affected E13.5 embryos, no patent oral cavity is detected, and the mandibular rudiment is continuous with the skull base

• however, mildly affected embryos with mandibular hypoplasia and microglossia have a patent oral cavity

cleft secondary palate ( J:251775 )

• late-gestation embryos exhibit a cleft secondary palate

delayed palatal shelf elevation ( J:251775 )

• when the tongue is present, palatal shelves are delayed in their elevation

absent tongue ( J:251775 )

• at E13.5, embryos with micrognathia typically fail to form a tongue (aglossia)

tongue hypoplasia ( J:251775 )

• at E13.5, micrognathia is less commonly associated with severe hypoplasia of the tongue

• however, embryos with mild to no facial hypoplasia exhibit a relatively normal tongue

proboscis ( J:251775 )

• overt cyclopia with a rostral proboscis is observed in 2 embryos

digestive/alimentary system

abnormal palatal shelf morphology ( J:251775 )

• at E13.5, embryos with aglossia exhibit expanded and irregular palatal shelves

• however, when the tongue is present, palatal shelves take on a more normal morphology

increased palatal shelf size ( J:251775 )

• at E13.5, embryos with aglossia exhibit dramatically expanded and bulbous palatal shelves that fill most of the oral cavity

cleft secondary palate ( J:251775 )

• late-gestation embryos exhibit a cleft secondary palate

delayed palatal shelf elevation ( J:251775 )

• when the tongue is present, palatal shelves are delayed in their elevation

absent tongue ( J:251775 )

• at E13.5, embryos with micrognathia typically fail to form a tongue (aglossia)

tongue hypoplasia ( J:251775 )

• at E13.5, micrognathia is less commonly associated with severe hypoplasia of the tongue

• however, embryos with mild to no facial hypoplasia exhibit a relatively normal tongue

growth/size/body

basisphenoid bone hypoplasia ( J:251775 )

• at E17.5, the basisphenoid bone is hypoplastic

abnormal mandible morphology ( J:251775 )

• at E17.5, the mandibular skeleton is severely dysmorphic and the hemimandibles are prematurely fused distally

absent mandible ( J:251775 )

• at E10.5, the mandible is variably affected, ranging from mild mandibular hypoplasia to agnathia

mandible hypoplasia ( J:251775 )

• at E10.5, the mandible is variably affected, ranging from mild mandibular hypoplasia to agnathia

premaxilla hypoplasia ( J:251775 )

• at E17.5, the maxilla/premaxilla are mildly hypoplastic

maxilla hypoplasia ( J:251775 )

• at E13.5, maxillary hypoplasia often accompanies mandibular hypoplasia

• at E17.5, the maxilla/premaxilla are mildly hypoplastic

abnormal palatine bone morphology ( J:251775 )

• at E17.5, the prepalatine bones are absent, and the palatine bones are reduced in length posteriorly

abnormal palatal shelf morphology ( J:251775 )

• at E13.5, embryos with aglossia exhibit expanded and irregular palatal shelves

• however, when the tongue is present, palatal shelves take on a more normal morphology

increased palatal shelf size ( J:251775 )

• at E13.5, embryos with aglossia exhibit dramatically expanded and bulbous palatal shelves that fill most of the oral cavity

decreased mouth size ( J:251775 )

abnormal oral cavity morphology ( J:251775 )

• in severely affected E13.5 embryos, no patent oral cavity is detected, and the mandibular rudiment is continuous with the skull base

• however, mildly affected embryos with mandibular hypoplasia and microglossia have a patent oral cavity

cleft secondary palate ( J:251775 )

• late-gestation embryos exhibit a cleft secondary palate

delayed palatal shelf elevation ( J:251775 )

• when the tongue is present, palatal shelves are delayed in their elevation

absent tongue ( J:251775 )

• at E13.5, embryos with micrognathia typically fail to form a tongue (aglossia)

tongue hypoplasia ( J:251775 )

• at E13.5, micrognathia is less commonly associated with severe hypoplasia of the tongue

• however, embryos with mild to no facial hypoplasia exhibit a relatively normal tongue

proboscis ( J:251775 )

• overt cyclopia with a rostral proboscis is observed in 2 embryos

nervous system

holoprosencephaly ( J:251775 )

• a single, small forebrain vesicle is frequently observed at E10.5

vision/eye

cyclopia ( J:251775 )

• overt cyclopia with a rostral proboscis is observed in 2 embryos

microphthalmia ( J:251775 )

• microphthalmia or anophthalmia is occasionally observed

anophthalmia ( J:251775 )

• microphthalmia or anophthalmia is occasionally observed

skeleton

abnormal basisphenoid bone morphology ( J:251775 )

• at E17.5, the basisphenoid shows long, ectopic lateral processes that pass below, but are not fused to the tympanic bullae

basisphenoid bone hypoplasia ( J:251775 )

• at E17.5, the basisphenoid bone is hypoplastic

abnormal zygomatic arch morphology ( J:251775 )

• at E17.5, the zygomatic arch is reduced in size

abnormal mandible morphology ( J:251775 )

• at E17.5, the mandibular skeleton is severely dysmorphic and the hemimandibles are prematurely fused distally

absent mandible ( J:251775 )

• at E10.5, the mandible is variably affected, ranging from mild mandibular hypoplasia to agnathia

mandible hypoplasia ( J:251775 )

• at E10.5, the mandible is variably affected, ranging from mild mandibular hypoplasia to agnathia

premaxilla hypoplasia ( J:251775 )

• at E17.5, the maxilla/premaxilla are mildly hypoplastic

maxilla hypoplasia ( J:251775 )

• at E13.5, maxillary hypoplasia often accompanies mandibular hypoplasia

• at E17.5, the maxilla/premaxilla are mildly hypoplastic

abnormal palatine bone morphology ( J:251775 )

• at E17.5, the prepalatine bones are absent, and the palatine bones are reduced in length posteriorly

respiratory system

abnormal pharynx morphology ( J:251775 )

• at E13.5, severely affected embryos show fusion of the mandibular rudiment with the roof of the oral cavity, resulting in complete occlusion of the pharynx; the pharynx distal to the occluded oral cavity is typically distended

• however, when the tongue is present, no occlusion of the pharynx is observed

hearing/vestibular/ear

abnormal auditory bulla morphology ( J:251775 )

• at E17.5, the tympanic bullae are translocated medially towards a hypoplastic basisphenoid