Phenotypes associated with this allele

• Allele Symbol: Scn1a^tm1Kea
• Allele Name: targeted mutation 1, Jennifer Kearney
• Allele ID: MGI:5510417
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Scn1a^tm1Kea/Scn1a^+	129S6/SvEvTac-Scn1a^tm1Kea	MGI:5523995
ht2	Scn1a^tm1Kea/Scn1a^+	(C57BL/6J x 129S6/SvEvTac-Scn1a^tm1Kea)F1	MGI:5523996

Genotype
MGI:5523995

ht1

• Allelic Composition: Scn1a^tm1Kea/Scn1a⁺
• Genetic Background: 129S6/SvEvTac-Scn1a^tm1Kea

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

normal phenotype

no abnormal phenotype detected ( J:203040 )

• Background Sensitivity: mice on a coisogenic 129S6/SvEvTac background exhibit no overt phenotype and a normal life span unlike mice on a background containing C57BL/6J

Genotype
MGI:5523996

ht2

• Allelic Composition: Scn1a^tm1Kea/Scn1a⁺
• Genetic Background: (C57BL/6J x 129S6/SvEvTac-Scn1a^tm1Kea)F1

mortality/aging

premature death ( J:203040 )

• Background Sensitivity: mice on a background containing C57BL/6J exhibit premature death with 50% of mice dying by 1 month of age unlike mice on a coisogenic 129S6/SvEvTac background

behavior/neurological

seizures ( J:203040 )

• Background Sensitivity: mice on a background containing C57BL/6J exhibit spontaneous seizures unlike mice on a coisogenic 129S6/SvEvTac background

nervous system

seizures ( J:203040 )

• Background Sensitivity: mice on a background containing C57BL/6J exhibit spontaneous seizures unlike mice on a coisogenic 129S6/SvEvTac background

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Dravet syndrome		DOID:0080422	OMIM:607208	J:203040