Phenotypes associated with this allele
Allelic Composition |
Ptentm1Engc/Ptentm1Engc
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Genetic Background |
either: (involves: 129 * CD-1) or (involves: 129 * A/J * C57BL/6J) or (involves: 129 * C57BL/6J * CD-1) |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Engc mutation
(0 available);
any
Pten mutation
(81 available)
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nervous system
growth/size/body
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• macrocephaly secondary to megencephaly regardless of background
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Engc mutation
(0 available);
any
Pten mutation
(81 available)
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behavior/neurological
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• latency to fall on the rotarod test is lower across all days, indicating poor balance
• however, mice show similar motor learning as wild-type mice on the accelerating rotarod test
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• males, but not females, exhibit increases in social motivation, with males showing greater variability in the preference for social novelty part of the three-chamber task, and a greater preference for the social target over non-social target in the amount of time spent in close proximity to the target
• however, mice show normal learning and recognition memory in the three chambered test and in a novel object recognition task, normal exploratory behavior in the open field, indicating no differences in anxiety-like behavior, and no differences in the heat-based tail-flick test indicating normal sensory perception
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cellular
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• mice exhibit increased proliferation in the cerebral cortex and hippocampus at P40
• hyperproliferation of the polydendrocyte (NG2) population within the cortex
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growth/size/body
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• males, but not females, are smaller at P40
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nervous system
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• microglia in the cerebral cortex and hippocampus show thicker and enlarged cell bodies, indicating microglial activation
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• cerebrum is larger in both males and females
• however, the hippocampus is not enlarged
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• dentate gyrus granule cells exhibit a 10% increase in soma size
• however, cerebellar granule cells exhibit normal soma size and normal number of cell processes
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• pyramidal cells of hippocampus exhibit a 23% increase in soma size
• however, dendrites of CA1 pyrmaidal cell neurons are normal
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• pyramidal cells of the cortex a 26% increase in soma size
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• increase in the number of astrocytes at P40
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• mice exhibit increased GFAP-staining throughout the cortex, indicating astrogliosis
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• increase in the number of oligodendrocytes at P40
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immune system
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• microglia in the cerebral cortex and hippocampus show thicker and enlarged cell bodies, indicating microglial activation
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hematopoietic system
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• microglia in the cerebral cortex and hippocampus show thicker and enlarged cell bodies, indicating microglial activation
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Allelic Composition |
Ptentm1Engc/Pten+
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Genetic Background |
either: (involves: 129 * CD-1) or (involves: 129 * A/J * C57BL/6J) or (involves: 129 * C57BL/6J * CD-1) |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Engc mutation
(0 available);
any
Pten mutation
(81 available)
|
|
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nervous system
growth/size/body
Allelic Composition |
Ptentm1Engc/Pten+
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Genetic Background |
involves: CD-1 |
|
Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ptentm1Engc mutation
(0 available);
any
Pten mutation
(81 available)
|
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cellular
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• increased proteasome activity and protein ubiquitination in brain tissue
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