Phenotypes associated with this allele

• Allele Symbol: Svep1^{tm1b(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1b, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5509058
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Svep1^tm1b(EUCOMM)Hmgu/Svep1^tm1b(EUCOMM)Hmgu	B6N(Cg)-Svep1^tm1b(EUCOMM)Hmgu/J	MGI:6115217
hm2	Svep1^tm1b(EUCOMM)Hmgu/Svep1^tm1b(EUCOMM)Hmgu	C57BL/6N-Svep1^tm1b(EUCOMM)Hmgu/J	MGI:5757780
ht3	Svep1^tm1b(EUCOMM)Hmgu/Svep1^+	C57BL/6N-Svep1^tm1b(EUCOMM)Hmgu/J	MGI:5757779

Genotype
MGI:6115217

hm1

• Allelic Composition: Svep1^{tm1b(EUCOMM)Hmgu}/Svep1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: B6N(Cg)-Svep1^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0747_6_B06

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:255307 )

• no homozygotes are identified at weaning

homeostasis/metabolism

edema ( J:255307 )

• E18.5 homozygotes exhibit edema

integument

acanthosis ( J:255307 )

• E18.5 homozygotes exhibit significant acanthosis relative to heterozygous controls

thick epidermis ( J:255307 )

• E18.5 homozygotes exhibit a significantly thicker epidermal layer relative to heterozygous controls

abnormal skin coloration ( J:255307 )

• E18.5 homozygotes exhibit abnormal skin coloration

limbs/digits/tail

abnormal limb morphology ( J:255307 )

• at E18.5

abnormal tail morphology ( J:255307 )

• at E18.5

Genotype
MGI:5757780

hm2

• Allelic Composition: Svep1^{tm1b(EUCOMM)Hmgu}/Svep1^{tm1b(EUCOMM)Hmgu}
• Genetic Background: C57BL/6N-Svep1^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0747_6_B06

Data Sources

IMPC Data for Svep1

homeostasis/metabolism

edema ( J:211773 )

IMPC - JAX

integument

abnormal skin appearance ( J:211773 )

IMPC - JAX

limbs/digits/tail

abnormal limb morphology ( J:211773 )

♂

IMPC - JAX

abnormal tail morphology ( J:211773 )

IMPC - JAX

mortality/aging

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:5757779

ht3

• Allelic Composition: Svep1^{tm1b(EUCOMM)Hmgu}/Svep1⁺
• Genetic Background: C57BL/6N-Svep1^{tm1b(EUCOMM)Hmgu}/J
• Cell Lines: HEPD0747_6_B06

Data Sources

IMPC Data for Svep1

cardiovascular system

prolonged QRS complex duration ( J:211773 )

♂

IMPC - JAX

hematopoietic system

increased erythrocyte cell number ( J:211773 )

♂

IMPC - JAX

increased hematocrit ( J:211773 )

♂

IMPC - JAX

increased hemoglobin content ( J:211773 )

♀

IMPC - JAX

homeostasis/metabolism

decreased circulating glucose level ( J:211773 )

♂

IMPC - JAX

decreased circulating phosphate level ( J:211773 )

♀

IMPC - JAX

decreased circulating sodium level ( J:211773 )

♀

IMPC - JAX