Phenotypes associated with this allele

• Allele Symbol: Cgn^tm1.1Citi
• Allele Name: targeted mutation 1.1, Sandra Citi
• Allele ID: MGI:5508663
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cgn^tm1.1Citi/Cgn^tm1.1Citi	B6.129-Cgn^tm1.1Citi	MGI:5508671

Genotype
MGI:5508671

hm1

• Allelic Composition: Cgn^tm1.1Citi/Cgn^tm1.1Citi
• Genetic Background: B6.129-Cgn^tm1.1Citi

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

digestive/alimentary system

digestive/alimentary phenotype ( J:200284 )

N • mice exhibit normal intestinal histology, intestinal permeability, inflammatory parameters, response to dextran sodium sulfate and tight junction structure

intestinal ulcer ( J:200284 )

• increased sensitivity to the ulcerogenic action of cysteamine

homeostasis/metabolism

increased susceptibility to injury ( J:200284 )

• cysteamine-treated mice exhibit increased ulcerogenic action in the duodenum compared with wild-type mice

• however, mice exhibit normal inflammatory and proliferation response