About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arhgef11tm1Sgkd
targeted mutation 1, Silvio Gutkind
MGI:5505410
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arhgef11tm1Sgkd/Arhgef11tm1Sgkd involves: 129 * C57BL/6J MGI:5505420
cx2
 		Arhgef11tm1Sgkd/Arhgef11tm1Sgkd
Arhgef12tm1Sgkd/Arhgef12tm1Sgkd 		involves: 129 * C57BL/6J MGI:5505422
cx3
 		Arhgef11tm1Sgkd/Arhgef11+
Arhgef12tm1Sgkd/Arhgef12tm1Sgkd 		involves: 129 * C57BL/6J MGI:5505423
cx4
 		Arhgef11tm1Sgkd/Arhgef11tm1Sgkd
Arhgef12tm1Sgkd/Arhgef12+ 		involves: 129 * C57BL/6J MGI:5505424


Genotype
MGI:5505420
hm1
Allelic
Composition		 Arhgef11tm1Sgkd/Arhgef11tm1Sgkd
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef11tm1Sgkd mutation (0 available); any Arhgef11 mutation (77 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:198274 )
• no obvious phenotype




Genotype
MGI:5505422
cx2
Allelic
Composition		 Arhgef11tm1Sgkd/Arhgef11tm1Sgkd
Arhgef12tm1Sgkd/Arhgef12tm1Sgkd
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef11tm1Sgkd mutation (0 available); any Arhgef11 mutation (77 available)
Arhgef12tm1Sgkd mutation (0 available); any Arhgef12 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Arhgef11tm1Sgkd/Arhgef11tm1Sgkd Arhgef12tm1Sgkd/Arhgef12tm1Sgkd embryos are less developed with partial branching failure of the cranial vessels

mortality/aging

embryo
embryo phenotype ( J:198274 )
N
• mice exhibit normal placental trophoblast layer proliferation and differentiation
abnormal placental labyrinth vasculature morphology ( J:198274 )
• fewer vessels at E9.5 that is more prominent at E10.5
abnormal vitelline vasculature morphology ( J:198274 )
• less visible blood vessels in the yolk sac at E10
disorganized yolk sac vascular plexus ( J:198274 )
• with dilated and not well oriented vessels
decreased embryo size ( J:198274 )
• smaller and less developed at E10

cardiovascular system
abnormal brain vasculature morphology ( J:198274 )
• partial branching failure in 2 of 6 cranial vessels and less vessel branching in the head
abnormal placental labyrinth vasculature morphology ( J:198274 )
• fewer vessels at E9.5 that is more prominent at E10.5
abnormal vascular development ( J:198274 )
• abnormal blood vessel distribution
• partial branching failure in 2 of 6 cranial vessels and less vessel branching in the head
• however, vessel branching in the trunk
abnormal vitelline vasculature morphology ( J:198274 )
• less visible blood vessels in the yolk sac at E10
disorganized yolk sac vascular plexus ( J:198274 )
• with dilated and not well oriented vessels

cellular
abnormal fibroblast proliferation ( J:198274 )
• mouse embryonic fibroblasts fail to exhibit increased proliferation in response to thrombin unlike control cells
decreased fibroblast proliferation ( J:198274 )
• in mouse embryonic fibroblast

growth/size/body
decreased embryo size ( J:198274 )
• smaller and less developed at E10

hematopoietic system
abnormal embryonic erythrocyte morphology ( J:198274 )
• fewer embryonic primitive erythrocytes

nervous system
abnormal brain vasculature morphology ( J:198274 )
• partial branching failure in 2 of 6 cranial vessels and less vessel branching in the head




Genotype
MGI:5505423
cx3
Allelic
Composition		 Arhgef11tm1Sgkd/Arhgef11+
Arhgef12tm1Sgkd/Arhgef12tm1Sgkd
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef11tm1Sgkd mutation (0 available); any Arhgef11 mutation (77 available)
Arhgef12tm1Sgkd mutation (0 available); any Arhgef12 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5505424
cx4
Allelic
Composition		 Arhgef11tm1Sgkd/Arhgef11tm1Sgkd
Arhgef12tm1Sgkd/Arhgef12+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef11tm1Sgkd mutation (0 available); any Arhgef11 mutation (77 available)
Arhgef12tm1Sgkd mutation (0 available); any Arhgef12 mutation (88 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:198274 )
• fewer than expected mice are produced




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory