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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Arhgef11tm1Sgkd
targeted mutation 1, Silvio Gutkind
MGI:5505410
Summary 4 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Arhgef11tm1Sgkd/Arhgef11tm1Sgkd involves: 129 * C57BL/6J MGI:5505420
cx2
 		Arhgef11tm1Sgkd/Arhgef11tm1Sgkd
Arhgef12tm1Sgkd/Arhgef12tm1Sgkd 		involves: 129 * C57BL/6J MGI:5505422
cx3
 		Arhgef11tm1Sgkd/Arhgef11+
Arhgef12tm1Sgkd/Arhgef12tm1Sgkd 		involves: 129 * C57BL/6J MGI:5505423
cx4
 		Arhgef11tm1Sgkd/Arhgef11tm1Sgkd
Arhgef12tm1Sgkd/Arhgef12+ 		involves: 129 * C57BL/6J MGI:5505424


Genotype
MGI:5505420
hm1
Allelic
Composition		 Arhgef11tm1Sgkd/Arhgef11tm1Sgkd
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef11tm1Sgkd mutation (0 available); any Arhgef11 mutation (75 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
normal phenotype
no abnormal phenotype detected ( J:198274 )
• no obvious phenotype




Genotype
MGI:5505422
cx2
Allelic
Composition		 Arhgef11tm1Sgkd/Arhgef11tm1Sgkd
Arhgef12tm1Sgkd/Arhgef12tm1Sgkd
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef11tm1Sgkd mutation (0 available); any Arhgef11 mutation (75 available)
Arhgef12tm1Sgkd mutation (0 available); any Arhgef12 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Arhgef11tm1Sgkd/Arhgef11tm1Sgkd Arhgef12tm1Sgkd/Arhgef12tm1Sgkd embryos are less developed with partial branching failure of the cranial vessels

mortality/aging

embryo
embryo phenotype ( J:198274 )
N
• mice exhibit normal placental trophoblast layer proliferation and differentiation
abnormal placental labyrinth vasculature morphology ( J:198274 )
• fewer vessels at E9.5 that is more prominent at E10.5
abnormal vitelline vasculature morphology ( J:198274 )
• less visible blood vessels in the yolk sac at E10
disorganized yolk sac vascular plexus ( J:198274 )
• with dilated and not well oriented vessels
decreased embryo size ( J:198274 )
• smaller and less developed at E10

cardiovascular system
abnormal brain vasculature morphology ( J:198274 )
• partial branching failure in 2 of 6 cranial vessels and less vessel branching in the head
abnormal placental labyrinth vasculature morphology ( J:198274 )
• fewer vessels at E9.5 that is more prominent at E10.5
abnormal vascular development ( J:198274 )
• abnormal blood vessel distribution
• partial branching failure in 2 of 6 cranial vessels and less vessel branching in the head
• however, vessel branching in the trunk
abnormal vitelline vasculature morphology ( J:198274 )
• less visible blood vessels in the yolk sac at E10
disorganized yolk sac vascular plexus ( J:198274 )
• with dilated and not well oriented vessels

cellular
abnormal fibroblast proliferation ( J:198274 )
• mouse embryonic fibroblasts fail to exhibit increased proliferation in response to thrombin unlike control cells
decreased fibroblast proliferation ( J:198274 )
• in mouse embryonic fibroblast

growth/size/body
decreased embryo size ( J:198274 )
• smaller and less developed at E10

hematopoietic system
abnormal embryonic erythrocyte morphology ( J:198274 )
• fewer embryonic primitive erythrocytes

nervous system
abnormal brain vasculature morphology ( J:198274 )
• partial branching failure in 2 of 6 cranial vessels and less vessel branching in the head




Genotype
MGI:5505423
cx3
Allelic
Composition		 Arhgef11tm1Sgkd/Arhgef11+
Arhgef12tm1Sgkd/Arhgef12tm1Sgkd
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef11tm1Sgkd mutation (0 available); any Arhgef11 mutation (75 available)
Arhgef12tm1Sgkd mutation (0 available); any Arhgef12 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging




Genotype
MGI:5505424
cx4
Allelic
Composition		 Arhgef11tm1Sgkd/Arhgef11tm1Sgkd
Arhgef12tm1Sgkd/Arhgef12+
Genetic
Background		 involves: 129 * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Arhgef11tm1Sgkd mutation (0 available); any Arhgef11 mutation (75 available)
Arhgef12tm1Sgkd mutation (0 available); any Arhgef12 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, incomplete penetrance ( J:198274 )
• fewer than expected mice are produced




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Send questions and comments to User Support. 		last database update
04/23/2024
MGI 6.23 		The Jackson Laboratory