All Phenotypes Mad2l2<tm1Ymu> MGI Mouse

mortality/aging

lethality during fetal growth through weaning, incomplete penetrance ( J:198275 )

• some mice die between E13.5 and after birth

reproductive system

decreased primordial germ cell number ( J:198275 )

• progressive

absent primordial germ cells ( J:198275 )

• at E13.5 in the genital ridge

increased primordial germ cell apoptosis ( J:198275 )

• increased PGC apoptosis during migration

• however, primordial germ cell development and migration are normal

absent ovarian follicles ( J:198275 )

small ovary ( J:198275 )

ovary atrophy ( J:198275 )

seminiferous tubule degeneration ( J:198275 )

• atrophic at P14 and P56

small testis ( J:198275 )

decreased testis weight ( J:198275 )

• at P14 and P56

abnormal oogenesis ( J:198275 )

• impaired

abnormal spermatogenesis ( J:198275 )

• impaired

azoospermia ( J:198275 )

female infertility ( J:198275 )

male infertility ( J:198275 )

growth/size/body

decreased embryo size ( J:198275 )

• at E10.5

decreased birth body size ( J:198275 )

decreased body size ( J:198275 )

• at P28

decreased body weight ( J:198275 )

• at P28, P42, P56 and P70

nervous system

nervous system phenotype ( J:198275 )

N	• neuroblast proliferation in the forebrain is normal at E11.5

increased forebrain apoptosis ( J:198275 )

• increased number of apoptotic cells among forebrain neuroblasts at E11.5

behavior/neurological

weakness ( J:198275 )

• feeble at birth

cellular