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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ightm1.1(b12)Nemz
targeted mutation 1.1, David Nemazee
MGI:5505302
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ightm1.1(b12)Nemz/Ightm1.1(b12)Nemz involves: C57BL/6N * FVB/N MGI:5550083
cx2
 		Ightm1.1(b12)Nemz/Ightm1.1(b12)Nemz
Igktm1.1(b12)Nemz/Igktm1.1(b12)Nemz 		involves: C57BL/6N * C57BL/6NTac * FVB/N MGI:5550085


Genotype
MGI:5550083
hm1
Allelic
Composition		 Ightm1.1(b12)Nemz/Ightm1.1(b12)Nemz
Genetic
Background		 involves: C57BL/6N * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1.1(b12)Nemz mutation (1 available); any Igh mutation (43 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased immature B cell number ( J:205766 )
• in the bone marrow
increased B cell number ( J:205766 )
• in the lymph node
decreased IgM level ( J:205766 )
• slightly

hematopoietic system
decreased immature B cell number ( J:205766 )
• in the bone marrow
increased B cell number ( J:205766 )
• in the lymph node
decreased IgM level ( J:205766 )
• slightly




Genotype
MGI:5550085
cx2
Allelic
Composition		 Ightm1.1(b12)Nemz/Ightm1.1(b12)Nemz
Igktm1.1(b12)Nemz/Igktm1.1(b12)Nemz
Genetic
Background		 involves: C57BL/6N * C57BL/6NTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ightm1.1(b12)Nemz mutation (1 available); any Igh mutation (43 available)
Igktm1.1(b12)Nemz mutation (1 available); any Igk mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
immune system phenotype ( J:205766 )
N
• B cells exhibit normal development, recognize HIV antigens, trigger normally and produce high levels of b12 IgG in serum
decreased immature B cell number ( J:205766 )
• in the bone marrow
increased B cell number ( J:205766 )
• in the lymph node
decreased IgM level ( J:205766 )
• slightly

hematopoietic system
decreased immature B cell number ( J:205766 )
• in the bone marrow
increased B cell number ( J:205766 )
• in the lymph node
decreased IgM level ( J:205766 )
• slightly




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory