Phenotypes associated with this allele

• Allele Symbol: Gabrg2^{tm1.1(Gabrg2)Wwis}
• Allele Name: targeted mutation 1.1, W Wisden
• Allele ID: MGI:5504520
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gabrg2^tm1.1(Gabrg2)Wwis/Gabrg2^tm1.1(Gabrg2)Wwis	involves: 129S1/Sv * 129X1/SvJ	MGI:5504535

Genotype
MGI:5504535

hm1

• Allelic Composition: Gabrg2^{tm1.1(Gabrg2)Wwis}/Gabrg2^{tm1.1(Gabrg2)Wwis}
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Reduced growth and abnormal posture of Gabrg2^{tm1.1(Gabrg2)Wwis}/Gabrg2^{tm1.1(Gabrg2)Wwis} mice (left)

mortality/aging

lethality at weaning, complete penetrance ( J:199326 )

• mice die around P20

behavior/neurological

impaired righting response ( J:199326 )

limb grasping ( J:199326 )

hunched posture ( J:199326 )

hyperactivity ( J:199326 )

nervous system

nervous system phenotype ( J:199326 )

N • mice exhibit normal brain assembly and normal sized GABAergic boutons unlike in Gabra1^tm1.1Geh homozygotes

abnormal inhibitory postsynaptic currents ( J:199326 )

• reduced synaptic activity, amplitude and frequency in Purkinje cells

growth/size/body

postnatal growth retardation ( J:199326 )