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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Shox2tm4.1Ypc
targeted mutation 4.1, YiPing Chen
MGI:5504510
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Shox2tm4.1Ypc/Shox2tm4.1Ypc involves: 129S6/SvEvTac * C57BL/6 MGI:5504522
ht2
 		Shox2tm3.1(cre)Ypc/Shox2tm4.1Ypc involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6 MGI:5504521


Genotype
MGI:5504522
hm1
Allelic
Composition		 Shox2tm4.1Ypc/Shox2tm4.1Ypc
Genetic
Background		 involves: 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shox2tm4.1Ypc mutation (0 available); any Shox2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
lethality throughout fetal growth and development, incomplete penetrance ( J:199319 )
• only a small number of surviving fetuses are observed by E14.5
embryonic lethality during organogenesis, incomplete penetrance ( J:199319 )
• lethality is observed beginning at E11.5, increasing as development progresses




Genotype
MGI:5504521
ht2
Allelic
Composition		 Shox2tm3.1(cre)Ypc/Shox2tm4.1Ypc
Genetic
Background		 involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shox2tm3.1(cre)Ypc mutation (0 available); any Shox2 mutation (19 available)
Shox2tm4.1Ypc mutation (0 available); any Shox2 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
embryonic lethality during organogenesis, incomplete penetrance ( J:199319 )
• lethality is observed beginning at E11.5, increasing as development progresses

cardiovascular system
sinoatrial node hypoplasia ( J:199319 )
• the sinoatrial node (SAN) is hypoplastic at E11.5 similar to Shox2tm1Ypc homozygous embryos

muscle
sinoatrial node hypoplasia ( J:199319 )
• the sinoatrial node (SAN) is hypoplastic at E11.5 similar to Shox2tm1Ypc homozygous embryos




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory