All Phenotypes Shox2<tm3.1(cre)Ypc> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Shox2^{tm3.1(cre)Ypc}
targeted mutation 3.1, YiPing Chen
MGI:5504508

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Shox2^{tm3.1(cre)Ypc}/Shox2^tm4.1Ypc	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6	MGI:5504521
cn2	Shox2^tm1Ddu/Shox2^{tm3.1(cre)Ypc}	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6	MGI:5504523

Allelic Composition	Shox2^{tm3.1(cre)Ypc}/Shox2^tm4.1Ypc
Genetic Background	involves: 129S1/Sv * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shox2^{tm3.1(cre)Ypc} mutation (0 available); any Shox2 mutation (19 available)
Shox2^tm4.1Ypc mutation (0 available); any Shox2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:199319 )

• no living fetuses are recovered at E14.5

embryonic lethality during organogenesis, incomplete penetrance ( J:199319 )

• lethality is observed beginning at E11.5, increasing as development progresses

cardiovascular system

sinoatrial node hypoplasia ( J:199319 )

• the sinoatrial node (SAN) is hypoplastic at E11.5 similar to Shox2^tm1Ypc homozygous embryos

muscle

sinoatrial node hypoplasia ( J:199319 )

• the sinoatrial node (SAN) is hypoplastic at E11.5 similar to Shox2^tm1Ypc homozygous embryos

Allelic Composition	Shox2^tm1Ddu/Shox2^{tm3.1(cre)Ypc}
Genetic Background	involves: 129S2/SvPas * 129S6/SvEvTac * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Shox2^tm1Ddu mutation (1 available); any Shox2 mutation (19 available)
Shox2^{tm3.1(cre)Ypc} mutation (0 available); any Shox2 mutation (19 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

lethality throughout fetal growth and development, complete penetrance ( J:199319 )

• no living fetuses are recovered at E14.5

embryonic lethality during organogenesis, incomplete penetrance ( J:199319 )

• lethality is observed beginning at E11.5, increasing as development progresses

cardiovascular system

sinoatrial node hypoplasia ( J:199319 )

• the sinoatrial node (SAN) is hypoplastic at E11.5 similar to Shox2^tm1Ypc homozygous embryos

muscle

sinoatrial node hypoplasia ( J:199319 )

• the sinoatrial node (SAN) is hypoplastic at E11.5 similar to Shox2^tm1Ypc homozygous embryos

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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