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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Itsn2tm1Egan
targeted mutation 1, Sean Egan
MGI:5503193
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Itsn2tm1Egan/Itsn2tm1Egan Not Specified MGI:5503220
cx2
 		Itsn1Gt(pT1ATGBetageo)1Ruiz/Itsn1Gt(pT1ATGBetageo)1Ruiz
Itsn2tm1Egan/Itsn2tm1Egan 		involves: 129S2/SvPas MGI:5503964


Genotype
MGI:5503220
hm1
Allelic
Composition		 Itsn2tm1Egan/Itsn2tm1Egan
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itsn2tm1Egan mutation (0 available); any Itsn2 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:196062 )
N
• mice exhibit normal brains morphology, hippocampal synaptic transmission and plasticity

behavior/neurological
behavior/neurological phenotype ( J:196062 )
N
• mice exhibit normal behavior




Genotype
MGI:5503964
cx2
Allelic
Composition		 Itsn1Gt(pT1ATGBetageo)1Ruiz/Itsn1Gt(pT1ATGBetageo)1Ruiz
Itsn2tm1Egan/Itsn2tm1Egan
Genetic
Background		 involves: 129S2/SvPas
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Itsn1Gt(pT1ATGBetageo)1Ruiz mutation (0 available); any Itsn1 mutation (100 available)
Itsn2tm1Egan mutation (0 available); any Itsn2 mutation (89 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
impaired contextual conditioning behavior ( J:196062 )
• mice exhibit less freezing compared with wild-type mice
abnormal spatial learning ( J:196062 )
• in a Morris water maze, mice fail to learn the location of a hidden platform and fail to exhibit a strong spatial bias for the zone where the platform was located unlike wild-type mice
impaired coordination ( J:196062 )
• impaired bimanual motor coordination in a grid test that is worse than in Itsn1Gt(pT1ATGBetageo)1Ruiz homozygotes

nervous system
abnormal brain white matter morphology ( J:196062 )
• the corpus callosum, ventral hippocampal commissure and anterior commissure exhibit a loss of fiber tracts compared with control mice

growth/size/body
decreased body weight ( J:196062 )
• as in Itsn1Gt(pT1ATGBetageo)1Ruiz homozygotes




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory