All Phenotypes Ighg1<tm1.1Pyu> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Ighg1^tm1.1Pyu
targeted mutation 1.1, Philipp Yu
MGI:5502698

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Ighg1^tm1.1Pyu/Ighg1^tm1.1Pyu	B6.C(Cg)-Ighg1^tm1.1Pyu	MGI:5502733
ht2	Ighg1^tm1.1Pyu/Ighg1⁺	B6.C(Cg)-Ighg1^tm1.1Pyu	MGI:5502732
cx3	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1^tm1.1Pyu	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J	MGI:5502734
cx4	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1⁺	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J	MGI:5502736

Allelic Composition	Ighg1^tm1.1Pyu/Ighg1^tm1.1Pyu
Genetic Background	B6.C(Cg)-Ighg1^tm1.1Pyu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1.1Pyu mutation (0 available); any Ighg1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice sensitized with TNP-ovalbumin

immune system

immune system phenotype ( J:198154 )

N	• unchallenged mice exhibit normal production of IgG1 • challenged mice exhibit normal production of IgM

increased IgE level ( J:198154 )

• in unchallenged mice and mice challenged with LPS and IL4

• mice challenged with TNP-ovalbumin produce 42-fold more antigen-specific IgE compared with wild-type mice

decreased IgG1 level ( J:198154 )

• absent in unchallenged mice and mice challenged with LPS and IL4

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2b level ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, unchallenged mice exhibit normal production of IgG2b

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop and mortality compared with wild-type mice

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice sensitized with TNP-ovalbumin

hematopoietic system

increased IgE level ( J:198154 )

• in unchallenged mice and mice challenged with LPS and IL4

• mice challenged with TNP-ovalbumin produce 42-fold more antigen-specific IgE compared with wild-type mice

decreased IgG1 level ( J:198154 )

• absent in unchallenged mice and mice challenged with LPS and IL4

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2b level ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, unchallenged mice exhibit normal production of IgG2b

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

Allelic Composition	Ighg1^tm1.1Pyu/Ighg1⁺
Genetic Background	B6.C(Cg)-Ighg1^tm1.1Pyu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighg1^tm1.1Pyu mutation (0 available); any Ighg1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:198154 )

N	• unchallenged mice exhibit normal production of IgG1 and IgG2b • challenged mice exhibit normal production of IgM

increased IgE level ( J:198154 )

• in unchallenged mice and mice challenged with LPS and IL4

• mice challenged with TNP-ovalbumin produce 11-fold more antigen-specific IgE compared with wild-type mice

decreased IgG1 level ( J:198154 )

• in mice challenged with LPS and IL4

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

hematopoietic system

increased IgE level ( J:198154 )

• in unchallenged mice and mice challenged with LPS and IL4

• mice challenged with TNP-ovalbumin produce 11-fold more antigen-specific IgE compared with wild-type mice

decreased IgG1 level ( J:198154 )

• in mice challenged with LPS and IL4

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

Allelic Composition	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1^tm1.1Pyu
Genetic Background	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fcer2a^tm1Max mutation (0 available); any Fcer2a mutation (24 available)
Ighg1^tm1.1Pyu mutation (0 available); any Ighg1 mutation (28 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

immune system

abnormal immunoglobulin level ( J:198154 )

• mice exhibit expression of membrane IgE in vitro but not in vivo

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop and mortality compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

hematopoietic system

abnormal immunoglobulin level ( J:198154 )

• mice exhibit expression of membrane IgE in vitro but not in vivo

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

Allelic Composition	Fcer2a^tm1Max/Fcer2a^tm1Max Ighg1^tm1.1Pyu/Ighg1⁺
Genetic Background	involves: 129 * BALB/cJ * C57BL/6 * C57BL/6J

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

immune system

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG1 level ( J:198154 )

• absent in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased susceptibility to type I hypersensitivity reaction ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop and mortality compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

homeostasis/metabolism

decreased body temperature ( J:198154 )

• mice sensitized with TNP-ovalbumin exhibit increased body temperature drop compared with wild-type mice

• however, depletion of basophils rescues anaphylactic overreactivity

increased susceptibility to xenobiotic induced morbidity/mortality ( J:198154 )

• in mice challenged with TNP-ovalbumin

• however, depletion of basophils rescues anaphylactic overreactivity

hematopoietic system

increased IgE level ( J:198154 )

• in mice challenged with TNP-ovalbumin

increased IgG2a level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG level ( J:198154 )

• in mice challenged with TNP-ovalbumin

decreased IgG1 level ( J:198154 )

• absent in mice challenged with TNP-ovalbumin

decreased IgG2c level ( J:198154 )

• in mice challenged with TNP-ovalbumin

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