|
Allele Symbol Allele Name Allele ID |
Tg(Myh6-EGFP/AC3I)#Mean transgene insertion, Mark Anderson MGI:5502606 |
||||||||||||
| Summary |
2 genotypes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• that is slightly less than in Ryr2tm2.1Wex homozygotes
• incidence of tachycardia in isoproterenol-treated mice is the same as in Ryr2tm2.1Wex homozygotes
|
|
|
| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
|
• STZ-treated mice subjected to myocardial infarction exhibit resistance to increased mortality compared with similarly treated wild-type mice
|
|
• STZ-treated mice subjected to myocardial infarction (MI) exhibit improved intrinsic sinus node function compared with similarly treated wild-type mice
|
|
• streptozotocin (STZ)-treated mice subjected to myocardial infarction (MI) exhibit resistance to increased mortality with increased resting heart rate, reduced episodes of very low heart rate, improved activity-related heart rate increases, improved intrinsic sinus node function, reduced apoptosis in the sinoatrial node and reduced fibrosis compared with similarly treated wild-type mice
• however, STZ mice subjected to MI exhibit normal left ventricle contractile function and volume
|
|
• streptozotocin (STZ)-treated mice subjected to myocardial infarction (MI) exhibit resistance to increased mortality with increased resting heart rate, reduced episodes of very low heart rate, improved activity-related heart rate increases, improved intrinsic sinus node function, reduced apoptosis in the sinoatrial node and reduced fibrosis compared with similarly treated wild-type mice
• however, STZ mice subjected to MI exhibit normal left ventricle contractile function and volume
|
|
• in the sinoatrial node of STZ-treated mice subjected to myocardial infarction
|
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
||
|
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support. |
last database update 05/07/2024 MGI 6.23 |
|
|
|
||
Analysis Tools