All Phenotypes Extl2<tm1Hkit> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Extl2^tm1Hkit
targeted mutation 1, Hiroshi Kitagawa
MGI:5502231

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Extl2^tm1Hkit/Extl2^tm1Hkit	B6.129P2-Extl2^tm1Hkit	MGI:5502304

Allelic Composition	Extl2^tm1Hkit/Extl2^tm1Hkit
Genetic Background	B6.129P2-Extl2^tm1Hkit

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Extl2^tm1Hkit mutation (0 available); any Extl2 mutation (16 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

cellular

abnormal cell morphology ( J:197845 )

• heparin sulfate and chondroitin sulfate levels in mouse embryonic fibroblasts, liver and brain are higher than in wild-type cells and tissues

• heparin sulfate and chondroitin sulfate sulfation in MEFs is lower than in wild-type cells

• however, sulfation in the brain and liver is normal

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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