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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Del(19Poll-Fbxw4)4Fsp
deletion, Chr 19, Francois Spitz 4
MGI:5501313
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cx1
 		Del(19Poll-Fbxw4)4Fsp/+
Fgf8tm1.4Mrt/Fgf8+ 		involves: 129P2/OlaHsd * 129S1/Sv MGI:5501452
cx2
 		Del(19Poll-Fbxw4)4Fsp/Del(19Poll-Fgf8)5Fsp involves: 129P2/OlaHsd * 129S1/Sv MGI:5501453


Genotype
MGI:5501452
cx1
Allelic
Composition		 Del(19Poll-Fbxw4)4Fsp/+
Fgf8tm1.4Mrt/Fgf8+
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Del(19Poll-Fbxw4)4Fsp mutation (0 available); any Del(19Poll-Fbxw4)4Fsp mutation (0 available)
Fgf8tm1.4Mrt mutation (0 available); any Fgf8 mutation (25 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
prenatal lethality, incomplete penetrance ( J:196292 )
• despite expected Mendelian ratios at E9.5 to E10.5, fewer than expected mice are present at E18.5

nervous system
abnormal brain morphology ( J:196292 )
• at E9.5 to E10.5
abnormal brain development ( J:196292 )
• deletion of midbrain/cerebellum structures

limbs/digits/tail
short limbs ( J:196292 )
• at E9.5 to E10.5

renal/urinary system

craniofacial

embryo
embryonic growth retardation ( J:196292 )
• at E9.5 to E10.5

growth/size/body
embryonic growth retardation ( J:196292 )
• at E9.5 to E10.5




Genotype
MGI:5501453
cx2
Allelic
Composition		 Del(19Poll-Fbxw4)4Fsp/Del(19Poll-Fgf8)5Fsp
Genetic
Background		 involves: 129P2/OlaHsd * 129S1/Sv
Find Mice Using the International Mouse Strain Resource (IMSR)
No mouse lines available in IMSR.
See publication links below for author information.
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
embryo
embryonic growth retardation ( J:196292 )
• at E9.5 to E10.5

growth/size/body
embryonic growth retardation ( J:196292 )
• at E9.5 to E10.5

limbs/digits/tail
short limbs ( J:196292 )
• at E9.5 to E10.5

nervous system
abnormal brain morphology ( J:196292 )
• at E9.5 to E10.5




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory