Phenotypes associated with this allele

• Allele Symbol: Birc2^tm2.1Jda
• Allele Name: targeted mutation 2.1, Jonathan D Ashwell
• Allele ID: MGI:5501232
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Birc2^tm2.1Jda/Birc2^tm2.1Jda	B6.Cg-Birc2^tm2.1Jda	MGI:5501261

Genotype
MGI:5501261

hm1

• Allelic Composition: Birc2^tm2.1Jda/Birc2^tm2.1Jda
• Genetic Background: B6.Cg-Birc2^tm2.1Jda

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:199221 )

N • mice exhibit normal B cell cellularity and function

increased T cell proliferation ( J:199221 )

• in response to anti-CD3 antibody stimulation but not as much as in T cells from Birc3^tm1Jda homozygotes

• however, proliferation in response to anti-CD3 and anti-CD28 antibody stimulation

increased interferon-gamma secretion ( J:199221 )

• in response to anti-CD3 antibody stimulation but not as much as in T cells from Birc3^tm1Jda homozygotes

• however, secretion in response to anti-CD3 and anti-CD28 antibody stimulation

hematopoietic system

increased T cell proliferation ( J:199221 )

• in response to anti-CD3 antibody stimulation but not as much as in T cells from Birc3^tm1Jda homozygotes

• however, proliferation in response to anti-CD3 and anti-CD28 antibody stimulation

cellular

increased T cell proliferation ( J:199221 )

• in response to anti-CD3 antibody stimulation but not as much as in T cells from Birc3^tm1Jda homozygotes

• however, proliferation in response to anti-CD3 and anti-CD28 antibody stimulation