Phenotypes associated with this allele

• Allele Symbol: Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan
• Allele Name: transgene insertion, Maike Sander
• Allele ID: MGI:5501130
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0 Tg(Neurog3-cre)C1Able/0	involves: BALB/c * C57BL/6	MGI:5501184
cn2	Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0 Tg(Gcg-cre)1Herr/0	involves: BALB/c * C57BL/6 * C57BL/6J * CBA/J	MGI:5501185

Genotype
MGI:5501184

cn1

• Allelic Composition: Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0; Tg(Neurog3-cre)C1Able/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:195153 )

N • islet cell mass and proliferation are normal

decreased pancreatic alpha cell number ( J:195153 )

increased pancreatic beta cell number ( J:195153 )

• at the expense of other islet cell types

decreased pancreatic delta cell number ( J:195153 )

decreased pancreatic epsilon cell number ( J:195153 )

homeostasis/metabolism

homeostasis/metabolism phenotype ( J:195153 )

N • mice exhibit normal glucose tolerance

Genotype
MGI:5501185

cn2

• Allelic Composition: Tg(CAG-Bgeo,-Nkx6-1,-EGFP)#Msan/0; Tg(Gcg-cre)1Herr/0
• Genetic Background: involves: BALB/c * C57BL/6 * C57BL/6J * CBA/J

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:195153 )

N • mice do not exhibit reprogramed differentiation of non-beta endocrine cells into beta cells