Phenotypes associated with this allele

• Allele Symbol: Trpm2^tm1.1Jych
• Allele Name: targeted mutation 1.1, Joseph Y Cheung
• Allele ID: MGI:5500054
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Trpm2^tm1.1Jych/Trpm2^tm1.1Jych	involves: FVB/N	MGI:5500055

Genotype
MGI:5500055

hm1

• Allelic Composition: Trpm2^tm1.1Jych/Trpm2^tm1.1Jych
• Genetic Background: involves: FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal myocardial fiber morphology ( J:196475 )

• following hydrogen peroxide exposure, cardiac myocytes exhibit reduced intracellular calcium compared with wild-type cells

increased heart left ventricle size ( J:196475 )

• increased left ventricular internal dimension during diastole and systole following ischemia and reperfusion

decreased cardiac muscle contractility ( J:196475 )

• following ischemia and reperfusion

abnormal myocardial fiber physiology ( J:196475 )

• following ischemia and reperfusion, myocytes exhibit a doubling of action potential duration after 50% depolarization compared with wild-type cells

increased response of heart to induced stress ( J:196475 )

• following ischemia and reperfusion, mice exhibit lower fractional shortening and ejection fraction and increased left ventricular internal dimension during diastole and systole compared with wild-type mice

• however, the area affected and mortality are normal

homeostasis/metabolism

increased response of heart to induced stress ( J:196475 )

• following ischemia and reperfusion, mice exhibit lower fractional shortening and ejection fraction and increased left ventricular internal dimension during diastole and systole compared with wild-type mice

• however, the area affected and mortality are normal

cellular

oxidative stress ( J:196475 )

• after hypoxia/reoxygenation, reactive oxygen species levels and oxygen free radical generation are increased compared to in wild-type myocytes

muscle

abnormal myocardial fiber morphology ( J:196475 )

• following hydrogen peroxide exposure, cardiac myocytes exhibit reduced intracellular calcium compared with wild-type cells

decreased cardiac muscle contractility ( J:196475 )

• following ischemia and reperfusion