Phenotypes associated with this allele

• Allele Symbol: Polr2h^{tm1.1(KOMP)Wtsi}
• Allele Name: targeted mutation 1.1, Wellcome Trust Sanger Institute
• Allele ID: MGI:5498773
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Polr2h^tm1.1(KOMP)Wtsi/Polr2h^tm1.1(KOMP)Wtsi	B6N(Cg)-Polr2h^tm1.1(KOMP)Wtsi/J	MGI:5763850
ht2	Polr2h^tm1.1(KOMP)Wtsi/Polr2h^+	B6N(Cg)-Polr2h^tm1.1(KOMP)Wtsi/J	MGI:5763849

Genotype
MGI:5763850

hm1

• Allelic Composition: Polr2h^{tm1.1(KOMP)Wtsi}/Polr2h^{tm1.1(KOMP)Wtsi}
• Genetic Background: B6N(Cg)-Polr2h^{tm1.1(KOMP)Wtsi}/J
• Cell Lines: EPD0374_5_A09

Data Sources

IMPC Data for Polr2h

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality prior to tooth bud stage ( J:211773 )

IMPC - JAX

embryonic lethality prior to organogenesis ( J:211773 )

IMPC - JAX

preweaning lethality, complete penetrance ( J:211773 )

IMPC - JAX

Genotype
MGI:5763849

ht2

• Allelic Composition: Polr2h^{tm1.1(KOMP)Wtsi}/Polr2h⁺
• Genetic Background: B6N(Cg)-Polr2h^{tm1.1(KOMP)Wtsi}/J
• Cell Lines: EPD0374_5_A09

Data Sources

IMPC Data for Polr2h

cardiovascular system

increased heart weight ( J:211773 )

♂

IMPC - JAX

growth/size/body

increased heart weight ( J:211773 )

♂

IMPC - JAX

homeostasis/metabolism

increased circulating free fatty acids level ( J:211773 )

IMPC - JAX

decreased circulating iron level ( J:211773 )

♀

IMPC - JAX

decreased circulating sodium level ( J:211773 )

♀

IMPC - JAX