Phenotypes associated with this allele

• Allele Symbol: Mad2l1^tm2Sorg
• Allele Name: targeted mutation 2, Peter K Sorg
• Allele ID: MGI:5498674
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Mad2l1^tm2Sorg/Mad2l1^tm2Sorg Tg(KRT14-cre)1Amc/?	Not Specified	MGI:5498676

Genotype
MGI:5498676

cn1

• Allelic Composition: Mad2l1^tm2Sorg/Mad2l1^tm2Sorg; Tg(KRT14-cre)1Amc/?
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:194539 )

• 80% die within one month of birth and remainder survive into adulthood

integument

hairless ( J:194539 )

abnormal hair follicle morphology ( J:194539 )

• hair follicles are abnormal at all stages

abnormal hair follicle bulge morphology ( J:194539 )

• bulge compartment of hair follicles depleted of cells

abnormal hair follicle physiology ( J:194539 )

• increased basal layer proliferation

abnormal epidermal layer morphology ( J:194539 )

hyperkeratosis ( J:194539 )

• during the first 3 weeks but becoming relatively normal later

abnormal skin physiology ( J:194539 )

• increased basal layer proliferation

cellular

aneuploidy ( J:194539 )

• increased numbers of chromosomes in epidermal cells