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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Med22tm1a(EUCOMM)Hmgu
targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
MGI:5497346
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Med22tm1a(EUCOMM)Hmgu/Med22tm1a(EUCOMM)Hmgu
Thtm1(cre)Te/Th+ 		involves: 129X1/SvJ * C57BL/6N MGI:6509609
cn2
 		Med22tm1a(EUCOMM)Hmgu/Med22+
Thtm1(cre)Te/Th+ 		involves: 129X1/SvJ * C57BL/6N MGI:6509610


Genotype
MGI:6509609
cn1
Allelic
Composition		 Med22tm1a(EUCOMM)Hmgu/Med22tm1a(EUCOMM)Hmgu
Thtm1(cre)Te/Th+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6N
Cell Lines HEPD0884_4_E12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med22tm1a(EUCOMM)Hmgu mutation (0 available); any Med22 mutation (12 available)
Thtm1(cre)Te mutation (1 available); any Th mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
preweaning lethality, complete penetrance ( J:300239 )
• no homozygous mice are produced from breeding heterozygotes, suggesting embryonic lethality; time of death not specified




Genotype
MGI:6509610
cn2
Allelic
Composition		 Med22tm1a(EUCOMM)Hmgu/Med22+
Thtm1(cre)Te/Th+
Genetic
Background		 involves: 129X1/SvJ * C57BL/6N
Cell Lines HEPD0884_4_E12
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Med22tm1a(EUCOMM)Hmgu mutation (0 available); any Med22 mutation (12 available)
Thtm1(cre)Te mutation (1 available); any Th mutation (57 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
renal/urinary system
renal/urinary system phenotype ( J:300239 )
N
• adult heterozygotes show no renal histological abnormalities up to 15 months of age; albuminuria (as measured by urine albumin/creatinine ratios), glomerulus basement membrane (GBM) thickness, and foot process width (as measured by slits/GBM length) are similar to those in control mice




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory