Phenotypes associated with this allele

• Allele Symbol: Med22^{tm1a(EUCOMM)Hmgu}
• Allele Name: targeted mutation 1a, Helmholtz Zentrum Muenchen GmbH
• Allele ID: MGI:5497346
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Med22^tm1a(EUCOMM)Hmgu/Med22^tm1a(EUCOMM)Hmgu Th^tm1(cre)Te/Th^+	involves: 129X1/SvJ * C57BL/6N	MGI:6509609
cn2	Med22^tm1a(EUCOMM)Hmgu/Med22^+ Th^tm1(cre)Te/Th^+	involves: 129X1/SvJ * C57BL/6N	MGI:6509610

Genotype
MGI:6509609

cn1

• Allelic Composition: Med22^{tm1a(EUCOMM)Hmgu}/Med22^{tm1a(EUCOMM)Hmgu}; Th^tm1(cre)Te/Th⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6N
• Cell Lines: HEPD0884_4_E12

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

preweaning lethality, complete penetrance ( J:300239 )

• no homozygous mice are produced from breeding heterozygotes, suggesting embryonic lethality; time of death not specified

Genotype
MGI:6509610

cn2

• Allelic Composition: Med22^{tm1a(EUCOMM)Hmgu}/Med22⁺; Th^tm1(cre)Te/Th⁺
• Genetic Background: involves: 129X1/SvJ * C57BL/6N
• Cell Lines: HEPD0884_4_E12

renal/urinary system

renal/urinary system phenotype ( J:300239 )

N • adult heterozygotes show no renal histological abnormalities up to 15 months of age; albuminuria (as measured by urine albumin/creatinine ratios), glomerulus basement membrane (GBM) thickness, and foot process width (as measured by slits/GBM length) are similar to those in control mice