Analysis Tools
hematopoietic system
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• mutant platelets have a defect in anchoring integrins to the underlying actin cytoskeleton
• mutant platelets adhered normally to collagen at low wall shear stresses and resisted detachment at wall shear stresses
• wild-type and knockout platelets adhered less well to fibrinogen
• mutant platelets adhered normally to fibrinogen at low wall shear stresses, although they detached modestly more frequently at high wall shear stresses
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homeostasis/metabolism
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• mutant platelets have a defect in anchoring integrins to the underlying actin cytoskeleton
• mutant platelets adhered normally to collagen at low wall shear stresses and resisted detachment at wall shear stresses
• wild-type and knockout platelets adhered less well to fibrinogen
• mutant platelets adhered normally to fibrinogen at low wall shear stresses, although they detached modestly more frequently at high wall shear stresses
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