Phenotypes associated with this allele

• Allele Symbol: Tcirg1^M1Jeau
• Allele Name: mutation 1, Jane Aubin
• Allele ID: MGI:5496553
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Tcirg1^M1Jeau/Tcirg1^+	either: (involves: C3H/HeJ * C57BL/6) or (involves: C3H/HeJ * C57BL/6 * FVB/N)	MGI:5496575

Genotype
MGI:5496575

ht1

• Allelic Composition: Tcirg1^M1Jeau/Tcirg1⁺
• Genetic Background: either: (involves: C3H/HeJ * C57BL/6) or (involves: C3H/HeJ * C57BL/6 * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

skeleton phenotype ( J:196503 )

N

abnormal osteoclast morphology ( J:196503 )

• osteoclasts exhibit ruffled borders compared with cells from wild-type mice

increased osteoclast cell number ( J:196503 )

• due to decreased apoptosis

abnormal osteoclast physiology ( J:196503 )

• decreased osteoclast apoptosis

increased bone mineral content ( J:196503 )

increased bone mineral density ( J:196503 )

abnormal trabecular bone morphology ( J:196503 )

• decreased bone marrow space

increased trabecular bone mass ( J:196503 )

immune system

abnormal osteoclast morphology ( J:196503 )

• osteoclasts exhibit ruffled borders compared with cells from wild-type mice

increased osteoclast cell number ( J:196503 )

• due to decreased apoptosis

abnormal osteoclast physiology ( J:196503 )

• decreased osteoclast apoptosis

hematopoietic system

abnormal osteoclast morphology ( J:196503 )

• osteoclasts exhibit ruffled borders compared with cells from wild-type mice

increased osteoclast cell number ( J:196503 )

• due to decreased apoptosis

abnormal osteoclast physiology ( J:196503 )

• decreased osteoclast apoptosis