About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Tecpr1tm1Chsa
targeted mutation 1, Chihiro Sasakawa
MGI:5496539
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Tecpr1tm1Chsa/Tecpr1tm1Chsa involves: 129S4/SvJae MGI:5496541


Genotype
MGI:5496541
hm1
Allelic
Composition		 Tecpr1tm1Chsa/Tecpr1tm1Chsa
Genetic
Background		 involves: 129S4/SvJae
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tecpr1tm1Chsa mutation (2 available); any Tecpr1 mutation (66 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
cellular
abnormal autophagy ( J:198333 )
• mouse embryonic fibroblasts pulsed with puromycin exhibit reduced clearance of ubiquitinated protein aggregates and accumulation of depolarized mitochondria compared with wild-type cells
• however, non-selective autophagy is normal

immune system
abnormal susceptibility to infection ( J:198333 )
• mouse embryonic fibroblasts infected with Shigella delta icsB exhibit increased survival of bacteria compared with control cells

homeostasis/metabolism
abnormal autophagy ( J:198333 )
• mouse embryonic fibroblasts pulsed with puromycin exhibit reduced clearance of ubiquitinated protein aggregates and accumulation of depolarized mitochondria compared with wild-type cells
• however, non-selective autophagy is normal




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory