Analysis Tools
mortality/aging
|
• mice die within 12 hours of birth
|
respiratory system
|
• 2-fold higher apoptosis in the lungs at E18.5 compared to in wild-type mice
• however, apoptosis rates are normal at E15.5
|
|
• increased glycogen level in the lungs at E18.5
|
|
• lung maturation is delayed
• lung air space is lower than in wild-type mice
• however, cell proliferation in the lungs is normal
|
|
• dilation is severely impaired with thicker septa than in wild-type mice
|
|
• thicker interstitial mesenchymal compartments at P0
|
small lung
(
J:196001
)
|
• at E18.5
|
|
• at E18.5
|
|
• reduced alveolar space
|
atelectasis
(
J:196001
)
|
• poorly expanded lobes with fissures at E18.5
• however, no hyaline membrane forms at P0
|
|
• failure to initiate normal breathing despite deep respiratory movements involving the whole-body muscles immediately after birth
|
homeostasis/metabolism
|
• increased glycogen level in the lungs at E18.5
|
cellular
|
• 2-fold higher apoptosis in the lungs at E18.5 compared to in wild-type mice
• however, apoptosis rates are normal at E15.5
|
growth/size/body
|
• in pups
|
