Phenotypes associated with this allele

• Allele Symbol: Thpr
• Allele Name: tooth hopper
• Allele ID: MGI:5496141
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ht1	Thpr/Thpr^+	B6.C3(B6Ei)-A Thpr/GrsrJ	MGI:5496387

Genotype
MGI:5496387

ht1

• Allelic Composition: Thpr/Thpr⁺
• Genetic Background: B6.C3(B6Ei)-A Thpr/GrsrJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Abnormal stance and smaller body size of a Thpr/Thpr⁺ mouse (lower) compared to wild-type sibling (upper)

behavior/neurological

abnormal motor coordination/balance ( J:198268 )

• heterozygotes often lean or fall over when moving

abnormal posture ( J:198268 )

abnormal resting posture ( J:198268 )

abnormal locomotor coordination ( J:198268 )

• hopping gait instead of moving legs in an opposing manner

ataxia ( J:198268 )

abnormal gait ( J:198268 )

• heterozygotes hop with their back legs moving together in synchrony instead of an opposing stride, and they sometimes lean or fall over when moving

abnormal maternal nurturing ( J:198268 )

♀ • heterozygous females do not care well for their young

craniofacial

abnormal jaw morphology ( J:198268 )

• lower jaw may be slightly longer than normal

abnormal tooth development ( J:198268 )

• teeth overgrow and supernumerary teeth may occur in the lower jaw

supernumerary teeth ( J:198268 )

malocclusion ( J:198268 )

skeleton

abnormal jaw morphology ( J:198268 )

• lower jaw may be slightly longer than normal

abnormal tooth development ( J:198268 )

• teeth overgrow and supernumerary teeth may occur in the lower jaw

supernumerary teeth ( J:198268 )

malocclusion ( J:198268 )

growth/size/body

abnormal jaw morphology ( J:198268 )

• lower jaw may be slightly longer than normal

abnormal tooth development ( J:198268 )

• teeth overgrow and supernumerary teeth may occur in the lower jaw

supernumerary teeth ( J:198268 )

malocclusion ( J:198268 )

decreased body size ( J:198268 )

mortality/aging

postnatal lethality, incomplete penetrance ( J:198268 )

• some heterozygotes do not survive to wean age, but most do if weaned late and provided with crushed meal

hearing/vestibular/ear

hearing/vestibular/ear phenotype ( J:198268 )

N • ABR indicates normal hearing

reproductive system

decreased litter size ( J:198268 )

♀ • heterozygotes produce smaller than normal litters

vision/eye

vision/eye phenotype ( J:198268 )

N • eye exams did not detect any abnormalities