Phenotypes associated with this allele

• Allele Symbol: Dbh^{tm1(flpo)Pjen}
• Allele Name: targeted mutation 1, Patricia Jensen
• Allele ID: MGI:5495939
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Dbh^tm1(flpo)Pjen/Dbh^tm1(flpo)Pjen	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5495968
ht2	Dbh^tm1(flpo)Pjen/Dbh^+	involves: 129S7/SvEvBrd * C57BL/6J	MGI:5495969

Genotype
MGI:5495968

hm1

• Allelic Composition: Dbh^{tm1(flpo)Pjen}/Dbh^{tm1(flpo)Pjen}
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis ( J:198264 )

• at E12.5, 4 homozygous embryos (identified from 25 total) are observed but are growth-retarded and dead or dying

prenatal lethality, complete penetrance ( J:198264 )

• no homozygous animals out of 32 pups are recovered at birth

Genotype
MGI:5495969

ht2

• Allelic Composition: Dbh^{tm1(flpo)Pjen}/Dbh⁺
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J

normal phenotype

no abnormal phenotype detected ( J:198264 )

• heterozygotes are indistinguishable from wild-type on gross inspection