All Phenotypes Wnt1<tm1.1Mze> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Wnt1^tm1.1Mze
targeted mutation 1.1, Mark Zervas
MGI:5495278

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
cn1	Wnt1^tm1.1Mze/Wnt1^tm1.1Mze Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ En1^tm2(cre)Wrst/En1⁺	involves: 129 * C57BL/6N	MGI:5495280
cn2	Wnt1^tm1.1Mze/Wnt1^tm1.1Mze En1^tm2(cre)Wrst/En1⁺	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N	MGI:5495279
cn3	Wnt1^tm1.1Mze/Wnt1^tm1.1Mze Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺	involves: 129S6/SvEvTac * C57BL/6N	MGI:5495282
cn4	Wnt1^tm1.1Mze/Wnt1^tm1.1Mze Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Wnt1-cre/ERT)1Alj/0	involves: 129S6/SvEvTac * C57BL/6N * Swiss Webster	MGI:5495281

Allelic Composition	Wnt1^tm1.1Mze/Wnt1^tm1.1Mze Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ En1^tm2(cre)Wrst/En1⁺
Genetic Background	involves: 129 * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm2(cre)Wrst mutation (1 available); any En1 mutation (32 available)
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (5 available); any Gt(ROSA)26Sor mutation (942 available)
Wnt1^tm1.1Mze mutation (0 available); any Wnt1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal rhombomere morphology ( J:194842 )

• rhombomere 1 is diminished with only a small domain adjacent to axonal bundles connected to the trigeminal ganglia

• dorsal rhombomere 1 is severely depleted but the ventral portion is less severely affected

abnormal midbrain morphology ( J:194842 )

• substantial depletion of the En1 lineage derived mesencephalon at E12.5

• dorsal mesencephalon is severely depleted but the ventral portion is less severely affected

abnormal hindbrain morphology ( J:194842 )

• severe truncation of the lateral anterior hindbrain

abnormal innervation ( J:194842 )

• aberrantly patterned whisker fields innervated by serotonergic neurons

decreased neuronal precursor cell number ( J:194842 )

• absence of LMX1a+ progenitors throughout the medial-lateral extent of the ventral mesencephalon and decreased numbers in the ventral diencephalon

decreased neuron number ( J:194842 )

• only a small disorganized cohort of TH+ MbDA neurons remain at E8.5

embryo

abnormal rhombomere morphology ( J:194842 )

• rhombomere 1 is diminished with only a small domain adjacent to axonal bundles connected to the trigeminal ganglia

• dorsal rhombomere 1 is severely depleted but the ventral portion is less severely affected

Allelic Composition	Wnt1^tm1.1Mze/Wnt1^tm1.1Mze En1^tm2(cre)Wrst/En1⁺
Genetic Background	involves: 129S1/Sv * 129X1/SvJ * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
En1^tm2(cre)Wrst mutation (1 available); any En1 mutation (32 available)
Wnt1^tm1.1Mze mutation (0 available); any Wnt1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased rhombomere 1 size ( J:194842 )

• severe deletion of rhombomere 1 at E10.5

abnormal midbrain morphology ( J:194842 )

• the ventral mesencephalon is dysmorphic

decreased midbrain size ( J:194842 )

• severe deletion of the putative mesencephalon at E10.5

embryo

decreased rhombomere 1 size ( J:194842 )

• severe deletion of rhombomere 1 at E10.5

Allelic Composition	Wnt1^tm1.1Mze/Wnt1^tm1.1Mze Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Shh^{tm1(EGFP/cre)Cjt}/Shh⁺
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (5 available); any Gt(ROSA)26Sor mutation (942 available)
Shh^{tm1(EGFP/cre)Cjt} mutation (1 available); any Shh mutation (45 available)
Wnt1^tm1.1Mze mutation (0 available); any Wnt1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

premature neuronal precursor differentiation ( J:194842 )

• significant increase of the number of differentiated MbDA neurons at E11.5

• significant increase in the number of Ki67+ progenitors in the differentiating zone in medial planes

abnormal midbrain morphology ( J:194842 )

• depletion of medial MbDA neurons and expansion of more laterally positioned MbDA neurons at E12.5

decreased neuron number ( J:194842 )

• depletion of medial MbDA neurons

cellular

premature neuronal precursor differentiation ( J:194842 )

• significant increase of the number of differentiated MbDA neurons at E11.5

• significant increase in the number of Ki67+ progenitors in the differentiating zone in medial planes

Allelic Composition	Wnt1^tm1.1Mze/Wnt1^tm1.1Mze Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze}/Gt(ROSA)26Sor⁺ Tg(Wnt1-cre/ERT)1Alj/0
Genetic Background	involves: 129S6/SvEvTac * C57BL/6N * Swiss Webster

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sor^{tm14(CAG-tdTomato)Hze} mutation (5 available); any Gt(ROSA)26Sor mutation (942 available)
Tg(Wnt1-cre/ERT)1Alj mutation (1 available)
Wnt1^tm1.1Mze mutation (0 available); any Wnt1 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

abnormal midbrain morphology ( J:194842 )

• following tamoxifen treatment at E8.5, the ventral mesencephalon is smaller and has an abnormal notch at E12.5

• depletion of TH+ neurons in the medial ventral mesencephalon and an increase in TH+ neurons in the off-midline plane in 2 of 4 embryos at E12.5

• tamoxifen treatment at E10.5 does not produce an overt phenotype in the mesencephalon

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