Phenotypes associated with this allele

• Allele Symbol: Slc10a4^tm1Tigm
• Allele Name: targeted mutation 1, Texas A&M Institute for Genomic Medicine
• Allele ID: MGI:5495143
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Slc10a4^tm1Tigm/Slc10a4^tm1Tigm	involves: 129S/SvEvBrd	MGI:5495145

Genotype
MGI:5495145

hm1

• Allelic Composition: Slc10a4^tm1Tigm/Slc10a4^tm1Tigm
• Genetic Background: involves: 129S/SvEvBrd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

seizures ( J:196996 )

• spontaneous

increased susceptibility to pharmacologically induced seizures ( J:196996 )

• high-grade seizure in pilocarpine injected mice

• however, mice exhibit normal sensitivity to kainic acid induced status epilepticus

abnormal spike wave discharge ( J:196996 )

• hippocampal slices exhibit increased spontaneous gamma-oscillation and decreased threshold to cholinergic stimulation with carbachol compared with wild-type slices

• mice exhibit spontaneous spike discharge unlike wild-type mice

• mice exhibit increased sensitivity to pilocarpine-induced status epilepticus compared with wild-type mice

• however, normal sensitivity to kainic acid induced status epilepticus

behavior/neurological

seizures ( J:196996 )

• spontaneous

increased susceptibility to pharmacologically induced seizures ( J:196996 )

• high-grade seizure in pilocarpine injected mice

• however, mice exhibit normal sensitivity to kainic acid induced status epilepticus

abnormal spike wave discharge ( J:196996 )

• hippocampal slices exhibit increased spontaneous gamma-oscillation and decreased threshold to cholinergic stimulation with carbachol compared with wild-type slices

• mice exhibit spontaneous spike discharge unlike wild-type mice

• mice exhibit increased sensitivity to pilocarpine-induced status epilepticus compared with wild-type mice

• however, normal sensitivity to kainic acid induced status epilepticus