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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp
targeted mutation 1.1, Giuseppe Pizzorno
MGI:5494989
Summary 1 genotype
Jump to Allelic Composition Genetic Background Genotype ID
ht1
 		Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+ involves: C57BL/6 * FVB/N MGI:5494998


Genotype
MGI:5494998
ht1
Allelic
Composition		 Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp/Gt(ROSA)26Sor+
Genetic
Background		 involves: C57BL/6 * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1.1(CAG-Upp1,-GFP)Gp mutation (2 available); any Gt(ROSA)26Sor mutation (1046 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
decreased fatty acid beta-oxidation ( J:195165 )
• reduced in hepatocytes
• however, supplementation with uridine restores fatty acid beta-oxidation

liver/biliary system
microvesicular hepatic steatosis ( J:195165 )
• hepatic microvesicular steatosis in untreated mice
• however, supplementation with uridine suppresses steatosis

cellular
decreased fatty acid beta-oxidation ( J:195165 )
• reduced in hepatocytes
• however, supplementation with uridine restores fatty acid beta-oxidation




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory