Phenotypes associated with this allele

• Allele Symbol: Tmem151b^{tm1b(KOMP)Wtsi}
• Allele Name: targeted mutation 1b, Wellcome Trust Sanger Institute
• Allele ID: MGI:5494963
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tmem151b^tm1b(KOMP)Wtsi/Tmem151b^tm1b(KOMP)Wtsi	C57BL/6N-Tmem151b^tm1b(KOMP)Wtsi/J	MGI:5631629
cx2	Tmem151b^tm1b(KOMP)Wtsi/Tmem151b^nmf389	B6N.Cg-Tmem151b^tm1b(KOMP)Wtsi/Tmem151b^nmf389/Frk	MGI:7868211

Genotype
MGI:5631629

hm1

• Allelic Composition: Tmem151b^{tm1b(KOMP)Wtsi}/Tmem151b^{tm1b(KOMP)Wtsi}
• Genetic Background: C57BL/6N-Tmem151b^{tm1b(KOMP)Wtsi}/J
• Cell Lines: EPD0479_2_H11

Data Sources

IMPC Data for Tmem151b

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal behavior ( J:211773 )

IMPC - JAX

decreased thigmotaxis ( J:211773 )

IMPC - JAX

hyperactivity ( J:211773 )

IMPC - JAX

abnormal sleep behavior ( J:211773 )

IMPC - JAX

abnormal seizure response to electrical stimulation ( J:362012 )

increased kindling response ( J:362012 )

• From assessments at 6 to 8 weeks of age, homozygous null females have a mean seizure threshold of 28.85 + 2.42 iRMS compared with 42.53 + 0 iRMS for C57BL/6NJ wildtype controls; homozygous null males have a mean seizure threshold of 40.51 + 5.12 iRMS compared with 48.11 + 0 iRMS for C57BL/6NJ wildtype controls.

homeostasis/metabolism

increased circulating sodium level ( J:211773 )

♀

IMPC - JAX

nervous system

abnormal seizure response to electrical stimulation ( J:362012 )

increased kindling response ( J:362012 )

• From assessments at 6 to 8 weeks of age, homozygous null females have a mean seizure threshold of 28.85 + 2.42 iRMS compared with 42.53 + 0 iRMS for C57BL/6NJ wildtype controls; homozygous null males have a mean seizure threshold of 40.51 + 5.12 iRMS compared with 48.11 + 0 iRMS for C57BL/6NJ wildtype controls.

Genotype
MGI:7868211

cx2

• Allelic Composition: Tmem151b^{tm1b(KOMP)Wtsi}/Tmem151b^nmf389
• Genetic Background: B6N.Cg-Tmem151b^{tm1b(KOMP)Wtsi}/Tmem151b^nmf389/Frk
• Cell Lines: EPD0479_2_H11

behavior/neurological

abnormal seizure response to electrical stimulation ( J:362012 )

increased kindling response ( J:362012 )

• From assessments at 6 to 8 weeks of age, compound heterozygous females have a mean seizure threshold of 29.50 + 1.08 iRMS and compound heterozygous males have a mean seizure threshold of 32.01 + 1.62 iRMS, each comparable with homozygous mutants and lower than single heterozygous mutants.

nervous system

abnormal seizure response to electrical stimulation ( J:362012 )

increased kindling response ( J:362012 )

• From assessments at 6 to 8 weeks of age, compound heterozygous females have a mean seizure threshold of 29.50 + 1.08 iRMS and compound heterozygous males have a mean seizure threshold of 32.01 + 1.62 iRMS, each comparable with homozygous mutants and lower than single heterozygous mutants.