All Phenotypes Pak2<tm1.1Cher> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Pak2^tm1.1Cher
targeted mutation 1, Jonathan Chernoff
MGI:5494659

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Pak2^tm1.1Cher/Pak2^tm1.1Cher	Not Specified	MGI:5494662

Allelic Composition	Pak2^tm1.1Cher/Pak2^tm1.1Cher
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Pak2^tm1.1Cher mutation (1 available); any Pak2 mutation (62 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

abnormal hematopoietic stem cell physiology ( J:195865 )

• LSK cells transduced with a cre-expressing retrovirus exhibit reduced homing to the bone marrow and decreased engraftment compared with control cells

• in transplantation experiments, LSK cells transduced with a cre-expressing retrovirus fail to contribute to recipient hematopoiesis unlike control cells

• however, cre-transduced cells retain colony forming activity

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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