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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Elovl4tm3Kzh
targeted mutation 3, Kang Zhang
MGI:5492043
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
cn1
 		Elovl4tm3Kzh/Elovl4tm3Kzh
Tg(Rho-icre)1Ck/? 		involves: C57BL/6 * SJL MGI:5492071
cn2
 		Elovl4tm3Kzh/Elovl4tm3Kzh
Tg(OPN1LW-cre)4Yzl/? 		involves: FVB/N MGI:5492072
cn3
 		Elovl4tm3Kzh/Elovl4tm3Kzh
Tg(Rho-cre)#Yzl/? 		Not Specified MGI:5492070


Genotype
MGI:5492071
cn1
Allelic
Composition		 Elovl4tm3Kzh/Elovl4tm3Kzh
Tg(Rho-icre)1Ck/?
Genetic
Background		 involves: C57BL/6 * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elovl4tm3Kzh mutation (0 available); any Elovl4 mutation (35 available)
Tg(Rho-icre)1Ck mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:194246 )
N
• no abnormalities
• normal ERG and normal visual performance up to 6.5 months
abnormal retina rod cell morphology ( J:194246 )
• statistically significant decrease in very long chain polyunsaturated fatty acid content of rods

homeostasis/metabolism
decreased unsaturated fatty acids level ( J:194246 )
• statistically significant decrease in very long chain polyunsaturated fatty acid content of rods
• decreases by 97.6%

nervous system
abnormal retina rod cell morphology ( J:194246 )
• statistically significant decrease in very long chain polyunsaturated fatty acid content of rods




Genotype
MGI:5492072
cn2
Allelic
Composition		 Elovl4tm3Kzh/Elovl4tm3Kzh
Tg(OPN1LW-cre)4Yzl/?
Genetic
Background		 involves: FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elovl4tm3Kzh mutation (0 available); any Elovl4 mutation (35 available)
Tg(OPN1LW-cre)4Yzl mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:194246 )
N
• normal ERG and normal visual performance up to 6.5 months

homeostasis/metabolism
homeostasis/metabolism phenotype ( J:194246 )
N
• very long chain polyunsaturated fatty acid content of rods not abnormally increased




Genotype
MGI:5492070
cn3
Allelic
Composition		 Elovl4tm3Kzh/Elovl4tm3Kzh
Tg(Rho-cre)#Yzl/?
Genetic
Background		 Not Specified
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Elovl4tm3Kzh mutation (0 available); any Elovl4 mutation (35 available)
Tg(Rho-cre)#Yzl mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:194246 )
N
• no rod loss
• no marked abnormalities in the number of photoreceptor cell rows or outer nuclear layer thickness
• no ultrastructural abnormalities
• normal ERG and normal visual performance up to 6.5 months
abnormal retina rod cell morphology ( J:194246 )
• statistically significant decrease in very long chain polyunsaturated fatty acid content of rods

homeostasis/metabolism
decreased unsaturated fatty acids level ( J:194246 )
• statistically significant decrease in very long chain polyunsaturated fatty acid content of rods

nervous system
abnormal retina rod cell morphology ( J:194246 )
• statistically significant decrease in very long chain polyunsaturated fatty acid content of rods




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory