All Phenotypes L1cam<tm4.1Vlem> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

L1cam^tm4.1Vlem
targeted mutation 4.1, Vance Lemmon
MGI:5491826

Summary

1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
ot1	L1cam^tm4.1Vlem/Y	either: 129S4.129S2-L1cam^tm4.1Vlem or B6.129S4-L1cam^tm4.1Vlem	MGI:5491872

Allelic Composition	L1cam^tm4.1Vlem/Y
Genetic Background	either: 129S4.129S2-L1cam^tm4.1Vlem or B6.129S4-L1cam^tm4.1Vlem

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
L1cam^tm4.1Vlem mutation (0 available); any L1cam mutation (12 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:197240 )

N	• mice exhibit normal survival

behavior/neurological

behavior/neurological phenotype ( J:197240 )

N	• mice exhibit normal spatial memory

impaired coordination ( J:197240 )

• on an accelerating rotarod

• however, mice are able to remain on an immobile rod without falling

nervous system

nervous system phenotype ( J:197240 )

N	• mice do not exhibit hydrocephalus and unmyelinated and myelinated axons

abnormal neurite morphology ( J:197240 )

• reduced number of branches and neurite total or longest neurite lengths when cultured on L1-Fc substrate

• reduced number of branches when cultured on laminin substrate

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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