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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Msrb1tm1.1Rlev
targeted mutation 1.1, Rodney L Levine
MGI:5490902
Summary 2 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Msrb1tm1.1Rlev/Msrb1tm1.1Rlev involves: BALB/cJ * C57BL/6 MGI:5490955
cx2
 		Msratm1Jmo/Msratm1Jmo
Msrb1tm1.1Rlev/Msrb1tm1.1Rlev 		involves: 129X1/SvJ * BALB/cJ * C57BL/6 MGI:5490957


Genotype
MGI:5490955
hm1
Allelic
Composition		 Msrb1tm1.1Rlev/Msrb1tm1.1Rlev
Genetic
Background		 involves: BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msrb1tm1.1Rlev mutation (1 available); any Msrb1 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
growth/size/body region phenotype ( J:196824 )
N
• mice exhibit normal growth regardless of methionine content in diet




Genotype
MGI:5490957
cx2
Allelic
Composition		 Msratm1Jmo/Msratm1Jmo
Msrb1tm1.1Rlev/Msrb1tm1.1Rlev
Genetic
Background		 involves: 129X1/SvJ * BALB/cJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Msratm1Jmo mutation (3 available); any Msra mutation (37 available)
Msrb1tm1.1Rlev mutation (1 available); any Msrb1 mutation (9 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
decreased body weight ( J:196824 )
• in mice fed a diet with 0.10% or 0.15% methionine unlike single homozygotes
• however, mice fed a diet with 0.45% methionine exhibit normal growth
postnatal growth retardation ( J:196824 )
• in mice fed a diet with 0.10% or 0.15% methionine unlike single homozygotes
• however, mice fed a diet with 0.45% methionine exhibit normal growth




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory