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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Rhotm4.1(RHO*/EGFP)Jhw
targeted mutation 4.1, John H Wilson
MGI:5490865
Summary 2 genotypes


Genotype
MGI:5490867
hm1
Allelic
Composition		 Rhotm4.1(RHO*/EGFP)Jhw/Rhotm4.1(RHO*/EGFP)Jhw
Genetic
Background		 B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm4.1(RHO*/EGFP)Jhw mutation (0 available); any Rho mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
retina degeneration ( J:196863 )
• rapid loss
abnormal rod electrophysiology ( J:196863 )
• lack an appreciable A wave at 1 month of age

nervous system




Genotype
MGI:5490868
ht2
Allelic
Composition		 Rhotm4.1(RHO*/EGFP)Jhw/Rho+
Genetic
Background		 B6.129S7-Rhotm4.1(RHO*/EGFP)Jhw
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Rhotm4.1(RHO*/EGFP)Jhw mutation (0 available); any Rho mutation (53 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
vision/eye
vision/eye phenotype ( J:196863 )
N
• responses of eyes to flashes of light of varying intensities at 1 month of age are similar to controls
abnormal retina morphology ( J:196863 )
• mislocalization of mutant rhodopsin to the inner segments and outer nuclear layer of the retina
retina degeneration ( J:196863 )
• very slow, similar to mice heterozygous for Rhotm2Jhw

Mouse Models of Human Disease
 DO ID OMIM ID(s) Ref(s)
retinitis pigmentosa 4 DOID:0110372 OMIM:613731
 J:196863




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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory