All Phenotypes Apaf1<ytj> MGI Mouse

Phenotypes associated with this allele

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Apaf1^ytj/Apaf1^ytj	involves: C3H/HeJ * C57BL/6J	MGI:5516425
ht2	Apaf1^fog/Apaf1^ytj	involves: C3H/HeJ * C57BL/6J	MGI:5516424

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

perinatal lethality, complete penetrance ( J:201947 )

• while live mice are present at E17.5, no viable mice are present at P0

craniofacial

abnormal craniofacial morphology ( J:201947 )

• in some mice as early as E12.5 with varying severity

abnormal frontal bone morphology ( J:201947 )

• frontal bone malformed around protruding brain tissue

absent interparietal bone ( J:201947 )

absent supraoccipital bone ( J:201947 )

absent parietal bone ( J:201947 )

abnormal presphenoid bone morphology ( J:201947 )

• in some mice

absent presphenoid bone ( J:201947 )

• in some mice

abnormal maxilla morphology ( J:201947 )

• cleft maxilla

broad frontonasal prominence ( J:201947 )

• widened frontonasal prominence

midline facial cleft ( J:201947 )

• separation of nasal bones and cartilage at the midline in some mice

nervous system

nervous system phenotype ( J:201947 )

N	• mice exhibit normal neural crest cell (existence and localization)

abnormal forebrain development ( J:201947 )

• flattened forebrain vesicles

exencephaly ( J:201947 )

limbs/digits/tail

interdigital webbing ( J:201947 )

vision/eye

failure of eyelid fusion ( J:201947 )

skeleton

abnormal frontal bone morphology ( J:201947 )

• frontal bone malformed around protruding brain tissue

absent interparietal bone ( J:201947 )

absent supraoccipital bone ( J:201947 )

absent parietal bone ( J:201947 )

abnormal presphenoid bone morphology ( J:201947 )

• in some mice

absent presphenoid bone ( J:201947 )

• in some mice

abnormal maxilla morphology ( J:201947 )

• cleft maxilla

growth/size/body

midline facial cleft ( J:201947 )

• separation of nasal bones and cartilage at the midline in some mice

Allelic Composition	Apaf1^fog/Apaf1^ytj
Genetic Background	involves: C3H/HeJ * C57BL/6J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apaf1^fog mutation (1 available); any Apaf1 mutation (78 available)
Apaf1^ytj mutation (1 available); any Apaf1 mutation (78 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

spina bifida ( J:201947 )

• with or without a kinked tail and wide or split face

abnormal forebrain development ( J:201947 )

• compressed forebrain ventricles

abnormal fourth ventricle morphology ( J:201947 )

• open

exencephaly ( J:201947 )

encephalomeningocele ( J:201947 )

craniofacial

abnormal craniofacial morphology ( J:201947 )

broad face ( J:201947 )

• wide face in some mice

facial cleft ( J:201947 )

• split face in some mice

limbs/digits/tail

kinked tail ( J:201947 )

• in some mice

skeleton

abnormal vertebrae morphology ( J:201947 )

• lumbosacral defects

embryo

spina bifida ( J:201947 )

• with or without a kinked tail and wide or split face

growth/size/body

broad face ( J:201947 )

• wide face in some mice

facial cleft ( J:201947 )

• split face in some mice

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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