All Phenotypes Heph<tm1.2Jdun> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Heph^tm1.2Jdun
targeted mutation 1.2, Joshua L Dunaief
MGI:5490638

Summary

2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Heph^tm1.2Jdun/Heph^tm1.2Jdun	involves: C57BL/6 * C57BL/6NTac	MGI:5490770
cx2	Cp^tm1Hrs/Cp^tm1Hrs Heph^tm1.2Jdun/Heph^tm1.2Jdun	involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac	MGI:5490771

Allelic Composition	Heph^tm1.2Jdun/Heph^tm1.2Jdun
Genetic Background	involves: C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Heph^tm1.2Jdun mutation (0 available); any Heph mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

integument

abnormal coat/ hair morphology ( J:196540 )

• mice lack body hair

• however, mice have facial hair and hair at the base of the tail

Allelic Composition	Cp^tm1Hrs/Cp^tm1Hrs Heph^tm1.2Jdun/Heph^tm1.2Jdun
Genetic Background	involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cp^tm1Hrs mutation (1 available); any Cp mutation (76 available)
Heph^tm1.2Jdun mutation (0 available); any Heph mutation (10 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

anemia ( J:196540 )

homeostasis/metabolism

abnormal iron level ( J:196540 )

• increased iron accumulation in the neural retina, retinal pigment epithelium cells and the choroid

nervous system

neurodegeneration ( J:196540 )

• neurodegenerative symptoms as in Cp^tm1Hrs Heph^sla double homozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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