Phenotypes associated with this allele

• Allele Symbol: Heph^tm1.2Jdun
• Allele Name: targeted mutation 1.2, Joshua L Dunaief
• Allele ID: MGI:5490638
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Heph^tm1.2Jdun/Heph^tm1.2Jdun	involves: C57BL/6 * C57BL/6NTac	MGI:5490770
cx2	Cp^tm1Hrs/Cp^tm1Hrs Heph^tm1.2Jdun/Heph^tm1.2Jdun	involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac	MGI:5490771

Genotype
MGI:5490770

hm1

• Allelic Composition: Heph^tm1.2Jdun/Heph^tm1.2Jdun
• Genetic Background: involves: C57BL/6 * C57BL/6NTac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

abnormal coat/ hair morphology ( J:196540 )

♀ • mice lack body hair

♀ • however, mice have facial hair and hair at the base of the tail

Genotype
MGI:5490771

cx2

• Allelic Composition: Cp^tm1Hrs/Cp^tm1Hrs; Heph^tm1.2Jdun/Heph^tm1.2Jdun
• Genetic Background: involves: 129X1/SvJ * C57BL/6 * C57BL/6NTac

hematopoietic system

anemia ( J:196540 )

♀

homeostasis/metabolism

abnormal iron level ( J:196540 )

♀ • increased iron accumulation in the neural retina, retinal pigment epithelium cells and the choroid

nervous system

neurodegeneration ( J:196540 )

♀ • neurodegenerative symptoms as in Cp^tm1Hrs Heph^sla double homozygotes