Phenotypes associated with this allele
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrltm1Jcco mutation
(1 available);
any
Nrl mutation
(17 available)
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nervous system
N |
• normal retinal development and function
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Rod reprogramming prevents retinal degeneration in tamoxifen treated Rhotm1Jlem/Rhotm1Jlem Nrltm1Jcco/Nrltm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 mice
vision/eye
N |
• photoreceptor death observed in Rhotm1Jlem homozygotes is prevented in tamoxifen-treated mice with preservation of rod cell bodies and inner segments and intact photopic b-wave over a wide range of flash intensities
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Nrltm1Jcco mutation
(1 available);
any
Nrl mutation
(17 available)
Tg(CAG-cre/Esr1*)5Amc mutation
(9 available)
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Adult rods are reprogrammed into cone-like cells in Nrltm1Jcco/Nrltm1Jcco Tg(CAG-cre/Esr1*)5Amc/0 mice
vision/eye
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• tamoxifen-treated mice exhibit reprogramming of rods into cone-like cells
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• in response to a series of light stimuli, reprogrammed retina in tamoxifen-treated mice exhibit lower maximal response amplitudes compared with control mice
• photopigment-bleached reprogrammed retina from tamoxifen-treated mice allowed to dark adapt in the presence of 9-cis-retinol are able to completely recover their photoresponse and largely restore their sensitivity
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• decreased scotopic a, but not b, wave amplitude in tamoxifen-treated mice
• like cone cells, dark-adapted reprogrammed rod cells in tamoxifen-treated mice exhibit a 35-fold desensitization and more rapid inactivation of photoresponse
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nervous system
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• tamoxifen-treated mice exhibit reprogramming of rods into cone-like cells
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