Phenotypes associated with this allele

• Allele Symbol: Tgfb1^tm1.1Mki
• Allele Name: targeted mutation 1.1, Masao Kakoki
• Allele ID: MGI:5490036
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Tgfb1^tm1.1Mki/Tgfb1^tm1.1Mki	C57BL/6-Tgfb1^tm1.1Mki	MGI:5490038

Genotype
MGI:5490038

hm1

• Allelic Composition: Tgfb1^tm1.1Mki/Tgfb1^tm1.1Mki
• Genetic Background: C57BL/6-Tgfb1^tm1.1Mki

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

hypovolemia ( J:194237 )

• plasma volume is decreased by approximately 50% compared to wild-type controls

homeostasis/metabolism

decreased circulating aldosterone level ( J:194237 )

• about 50% of wild-type levels at 12 weeks of age

increased circulating angiotensinogen level ( J:194237 )

• approximately 200% of wild-type levels

increased circulating renin level ( J:194237 )